English: Keratinocytes from a severely burnt patient were isolated from a biopsy of unaffected skin and keratinocytes SC colonies, called holoclones, were cultivated in vitro for 2 or 3 weeks to form sheets of epidermal cells. These epidermal sheets were grafted onto the patient burnt skin following Barrandon and Green's procedure. The graft skin is well differentiated and similar to non-grafted skin except the lack of hair follicle and sebaceous gland. Reprint by permission from Lippincott, Williams and Wilkins; Ronfard et al., Transplantation 2000).