Žučna kiselina-KoA:aminokiselina N-aciltransferaza
Žučna kiselina-KoA:aminokiselina N-aciltransferaza (EC 2.3.1.65, glicin-taurin N-aciltransferaza, amino kiselina N-holoiltransferaza, BAT, glicinska N-holoiltransferaza, BACAT, holil-KoA glicin-taurin N-aciltransferaza, holil-KoA:taurin N-aciltransferaza) je enzim sa sistematskim imenom holoil-KoA:glicin N-holoiltransferaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Žučna kiselina-KoA:aminokiselina N-aciltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.65 | ||||||||
| CAS broj | 65979-40-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- holoil-KoA + glicin KoA + glikoholat
Ovaj enzim takođe deluje na KoA derivate drugig žučnih kiselina. Taurin i 2-fluoro-beta-alanin mogu da deluju kao supstrati, mada sporije.
Reference уреди
- ^ Czuba, B. & Vessey, D.A. (1980). „Kinetic characterization of cholyl-CoA glycine-taurine N-acyltransferase from bovine liver”. J. Biol. Chem. 255: 5296—5299. PMID 7372637.
- ^ Jordan, T.W., Lee, R. and Lim, W.C. (1980). „Isoelectric focussing of soluble and particulate benzoyl-CoA and cholyl-CoA:amino acid N-acyltransferases from rat liver”. Biochem. Int. 1: 325—330.
- ^ Vessey, D.A. (1979). „The co-purification and common identity of cholyl CoA:glycine- and cholyl CoA:taurine-N-acyltransferase activities from bovine liver”. J. Biol. Chem. 254: 2059—2063. PMID 422567.
- ^ Johnson, M.R., Barnes, S., Kwakye, J.B. and Diasio, R.B. (1991). „Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver”. J. Biol. Chem. 266: 10227—10233. PMID 2037576.
- ^ Falany, C.N., Xie, X., Wheeler, J.B., Wang, J., Smith, M., He, D. and Barnes, S. (2002). „Molecular cloning and expression of rat liver bile acid CoA ligase”. J. Lipid Res. 43: 2062—2071. PMID 12454267.
- ^ He, D., Barnes, S. and Falany, C.N. (2003). „Rat liver bile acid CoA:amino acid N-acyltransferase: expression, characterization, and peroxisomal localization”. J. Lipid Res. 44: 2242—2249. PMID 12951368.
- ^ O'Byrne, J., Hunt, M.C., Rai, D.K., Saeki, M. and Alexson, S.E. (2003). „The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine”. J. Biol. Chem. 278: 34237—34244. PMID 12810727.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Bile+acid-CoA:amino+acid+N-acyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
