(+)-Epikubenolna sintaza
(+)-Epikubenolna sintaza (EC 4.2.3.64, farnezil pirofosfatna ciklaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira (+)-epikubenol).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (+)-Epikubenolna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.64 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnezil difosfat +H2O (+)-epikubenol + difosfat
Za dejstvo ovog enzima je neophodan jon Mg2+.
Reference уреди
- ^ Cane, D.E.; Tandon, M.; Prabhakaran, P.C. (1993). „Epicubenol synthase and the enzymatic cyclization of farnesyl diphosphate”. J. Am. Chem. Soc. 115: 8103—8106.
- ^ Cane, D.E.; Tandon, M. (1994). „Biosynthesis of (+)-epicubenol.”. Tetrahedron Lett. 35: 5355—5358.
- ^ Cane, D.E.; Tandon, M. (1995). „Epicubenol synthase and the stereochemistry of the enzymatic cyclization of farnesyl and nerolidyl diphosphate”. J. Am. Chem. Soc. 117: 5602—5603.
- ^ Nabeta, K.; Kigure, K.; Fujita, M.; Nagoya, T.; Ishikawa, T.; Okuyama, H.; Takasawa, T. (1995). „Bioynthesis of (+)-cubenene and (+)-epicubenol by cell-free extracts of cultured cells of Heteroscyphus planus and cyclization of [2H]farnesyl diphosphates”. J. Chem. Soc., Perkin Trans. 1: 1935—1939.
- ^ Nabeta, K.; Fujita, M.; Komuro, K.; Katayama, K.; Takasawa, T. (1997). „In vitro biosynthesis of cadinanes by cell-free extracts of cultured cells of Heteroscyphus planus”. J. Chem. Soc., Perkin Trans. 1: 2065—2070.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- (+)-epicubenol+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
