1,8-Cineol 2-endo-monooksigenaza
1,8-Cineol 2-endo-monooksigenaza (EC 1.14.13.156, P450cin, CYP176A, CYP176A1) je enzim sa sistematskim imenom 1,8-cineol,NADPH:kiseonik oksidoreduktaza (2-endo-hidroksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 1,8-Cineol 2-endo-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.156 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 1,8-cineol + NADPH + H+ + O2 2-endo-hidroksi-1,8-cineol + NADP+ + H2O
Ovaj enzim je hem-tiolatni protein (P-450) koji koristi flavodoksinu sličnog redoks partnera da redukuje gvožđehema.
Reference уреди
- ^ Hawkes, D.B., Adams, G.W., Burlingame, A.L., Ortiz de Montellano, P.R. and De Voss, J.J. (2002). „Cytochrome P450cin (CYP176A), isolation, expression, and characterization”. J. Biol. Chem. 277: 27725—27732. PMID 12016226.
- ^ Meharenna, Y.T., Li, H., Hawkes, D.B., Pearson, A.G., De Voss, J. and Poulos, T.L. (2004). „Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam”. Biochemistry. 43: 9487—9494. PMID 15260491.
- ^ Kimmich, N., Das, A., Sevrioukova, I., Meharenna, Y., Sligar, S.G. and Poulos, T.L. (2007). „Electron transfer between cytochrome P450cin and its FMN-containing redox partner, cindoxin”. J. Biol. Chem. 282: 27006—27011. PMID 17606612.
- ^ Meharenna, Y.T., Slessor, K.E., Cavaignac, S.M., Poulos, T.L. and De Voss, J.J. (2008). „The critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in p450cin”. J. Biol. Chem. 283: 10804—10812. PMID 18270198.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- 1,8-cineole+2-endo-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
