12-O-Tetradekanoilforbol-13-acetat

12-O-Tetradekanoilforbol-13-acetat
Nazivi
	IUPAC naziv (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetiloksi)-4a,7b-dihidroksi-3-(hidroksimetil)-1,1,6,8-tetrametil-5-okso-1a,1b,4,4a,5,7a,7b,8,9,9a-dekahidro-H-ciklopropa[3,4]benzo[1,2-e]azulen-9-il miristat
	Drugi nazivi TPA, PMA, Forbol miristat acetat,; Tetradekanoilforbol acetat.
Identifikacija
CAS broj	16561-29-8 ;
3D model (Jmol)	interaktivna slika;
ChemSpider	17215855 ;
ECHA InfoCard	100.109.485
KEGG	C05151 ;
PubChem C ID	10475874;
	SMILES CCCCCCCCCCCCCC(=O)O[C@@H]2C(C)[C@]1(O)C4/C=C(/C)C(=O)[C@@]4(O)CC(\CO)=C/[C@H]1[C@H]3[C@]2(OC(C)=O)C3(C)C; ; ; ; ; ;
Svojstva
Hemijska formula	C36H56O8
Molarna masa	616,83 g/mol
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

12-O-tetradekanoilforbol-13-acetat (TPA) (tetradekanoilforbol acetat, tetradekanoil forbol acetat, forbol 12-miristat 13-acetat, PMA) je diestar forbola i potentan promoter tumora koji se često koristi u biomedicinskim istraživanjima za aktiviranje prenosa signala enzima proteinska kinaza C (PKC).^[4]^[5]^[6] TPA deluje na PKC usled njegove sličnosti sa prirodnim aktivatorom klasičnih PKC izoformi, diacilglicerolom.

TPA se istražuje kao potencijalni lek za tretman hematološkog kancera.

Reference уреди

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Castagna; et al. (1982). „Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters”. Journal of Biological Chemistry. 257 (13): 7847—7851. PMID 7085651. doi:10.1016/S0021-9258(18)34459-4  .
^ Blumberg (1988). „Protein kinase C as the receptor for the phorbol ester tumor promoters: Sixth Rhoads memorial award lecture”. Cancer Research. 48 (1): 1—8. PMID 3275491.
^ Niedel; et al. (1983). „Phorbol Diester Receptor Copurifies with Protein Kinase C”. Proceedings of the National Academy of Sciences. 80 (1): 36—40. Bibcode:1983PNAS...80...36N. PMC 393304  . PMID 6296873. doi:10.1073/pnas.80.1.36  .

Spoljašnje veze уреди

Tetradecanoylphorbol+Acetate на US National Library of Medicine Medical Subject Headings (MeSH)
„NCI Dictionary Entry”. Архивирано из оригинала 01. 09. 2005. г. Приступљено 02. 07. 2005. Архивирано на сајту Wayback Machine (1. септембар 2005)
„Phase 1 Clinical Trials”. Приступљено 02. 07. 2005.

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[4] Castagna; et al. (1982). „Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters”. Journal of Biological Chemistry. 257 (13): 7847—7851. PMID 7085651. doi:10.1016/S0021-9258(18)34459-4  .

[5] Blumberg (1988). „Protein kinase C as the receptor for the phorbol ester tumor promoters: Sixth Rhoads memorial award lecture”. Cancer Research. 48 (1): 1—8. PMID 3275491.

[6] Niedel; et al. (1983). „Phorbol Diester Receptor Copurifies with Protein Kinase C”. Proceedings of the National Academy of Sciences. 80 (1): 36—40. Bibcode:1983PNAS...80...36N. PMC 393304  . PMID 6296873. doi:10.1073/pnas.80.1.36  .

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