3a,7a,12a-trihidroksi-5b-holest-24-enoil-KoA dehidrataza
3a,7a,12a-trihidroksi-5b-holest-24-enoil-KoA dehidrataza (EC 4.2.1.107, 46 kDa hidrataza 2, (24R,25R)-3alfa,7alfa,12alfa,24-tetrahidroksi-5beta-holestanoil-KoA hidrolijaza) je enzim sa sistematskim imenom (24R,25R)-3alfa,7alfa,12alfa,24-tetrahidroksi-5beta-holestanoil-KoA hidrolijaza (formira (24E)-3alfa,7alfa,12alfa-trihidroksi-5beta-holest-24-enoil-KoA).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3a,7a,12a-trihidroksi-5b-holest-24-enoil-KoA dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.107 | ||||||||
| CAS broj | 152787-68-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (24R,25R)-3alfa,7alfa,12alfa,24-tetrahidroksi-5beta-holestanoil-KoA (24E)-3alfa,7alfa,12alfa-trihidroksi-5beta-holest-24-enoil-KoA + H2O
Ovaj enzim je deo peroksizomalnog multifunktionalnog enzim perMFE-2 kod pacova.
Reference уреди
- ^ Qin, Y.M., Haapalainen, A.M., Conry, D., Cuebas, D.A., Hiltunen, J.K. and Novikov, D.K. (1997). „Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis”. Biochem. J. 328: 377—382. PMID 9371691.
- ^ Xu, R. & Cuebas, D.A. (1996). „The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids”. Biochem. Biophys. Res. Commun. 221: 271—278. PMID 8619845.
- ^ Kinoshita, T., Miyata, M., Ismail, S.M., Fujimoto, Y., Kakinuma, K., Kokawa, N.I. and Morisaki, M. (1988). „Synthesis and determination of stereochemistry of four diastereoisomers at the C-24 and C-25 positions of 3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid and cholic acid”. Chem. Pharm. Bull. 36: 134—141.
- ^ Fujimoto, Y., Kinoshita, T., Oya, I., Kakinuma, K., Ismail, S.M., Sonoda, Y., Sato, Y. and Morisaki, M. (1988). „Non-stereoselective conversion of the four diastereoisomers at the C-24 and C-25 positions of 3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid and cholic acid”. Chem. Pharm. Bull. 36: 142—145.
- ^ Kurosawa, T., Sato, M., Nakano, H., Fujiwara, M., Murai, T., Yoshimura, T. and Hashimoto, T. (2001). „Conjugation reactions catalyzed by bifunctional proteins related to β-oxidation in bile acid biosynthesis”. Steroids. 66: 107—114. PMID 11146090.
- ^ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137—174. PMID 12543708.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA+hydratase на US National Library of Medicine Medical Subject Headings (MeSH)
