77-LH-28-1

77-LH-28-1
Nazivi
	IUPAC naziv 1-[3-(4-Butil-1-piperidinol)propil]-3,4-dihidro-2(1H)-hinolinon
Identifikacija
CAS broj	560085-11-2 ;
3D model (Jmol)	interaktivna slika;
ChemSpider	8412246 ;
PubChem C ID	10236758;
	SMILES O=C2N(c1ccccc1CC2)CCCN3CCC(CC3)CCCC; ; ; ; ; ;
Svojstva
Hemijska formula	C21H32N2O
Molarna masa	328,50 g·mol−1
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

77-LH-28-1 je nedavno otkriveni selektivni agonist muskarinskog acetilholinskog receptora podtipa 1 (M₁). On je alosterni agonist, sa preko 100-puta većom specifičnošću za M₁ u odnosu na druge podtipove muskarinskog receptora. 77-LH-28-1 penetrira mozak prolazeći kroz krvno moždanu barijeru i stoga je korisno farmakološko oruđe sa efektima povećanja spoznaje.^[3]

Reference уреди

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ C J Langmead; N E Austin; C L Branch; J T Brown; K A Buchanan; C H Davies; I T Forbes; V A H Fry; J J Hagan; H J Herdon; G A Jones; R Jeggo; J N C Kew; A Mazzali; R Melarange; N Patel; J Pardoe; A D Randall; C Roberts; A Roopun; K R Starr; A Teriakidis; M D Wood; M Whittington; Z Wu & J Watson (2008). „Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1”. Br J Pharmacol. 154 (5): 1104—1115. PMC 2451039  . PMID 18454168. doi:10.1038/bjp.2008.152.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[3] C J Langmead; N E Austin; C L Branch; J T Brown; K A Buchanan; C H Davies; I T Forbes; V A H Fry; J J Hagan; H J Herdon; G A Jones; R Jeggo; J N C Kew; A Mazzali; R Melarange; N Patel; J Pardoe; A D Randall; C Roberts; A Roopun; K R Starr; A Teriakidis; M D Wood; M Whittington; Z Wu & J Watson (2008). „Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1”. Br J Pharmacol. 154 (5): 1104—1115. PMC 2451039  . PMID 18454168. doi:10.1038/bjp.2008.152.

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