Benzoil-KoA reduktaza
Benzoil-KoA reduktaza (EC 1.3.7.8, benzoil-KoA reduktaza (dearomatizacija)) je enzim sa sistematskim imenom cikloheksa-1,5-dien-1-karbonil-KoA:feredoksin oksidoreduktaza (aromatizacija, formira ATP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Benzoil-KoA reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.7.8 | ||||||||
| CAS broj | 176591-18-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- cikloheksa-1,5-dien-1-karbonil-KoA + oksidovani feredoksin + 2 ADP + 2 fosfat benzoil-KoA + redukovani feredoksin + 2 ATP + 2H2O
Ovaj enzim je gvožđe-sumporni protein. Za njegov rad je neophodan Mg2+ ili Mn2+. Neaktivan je prema aromatičnnim kiselinama koje nisu KoA esteri.
Reference уреди
- ^ Boll, M. & Fuchs, G. (1995). „Benzoyl-coenzyme A reductase (dearomatizing), a key enzyme of anaerobic aromatic metabolism. ATP dependence of the reaction, purification and some properties of the enzyme from Thauera aromatica strain K172”. Eur. J. Biochem. 234: 921—933. PMID 8575453.
- ^ Kung, J.W., Baumann, S., von Bergen, M., Muller, M., Hagedoorn, P.L., Hagen, W.R. and Boll, M. (2010). „Reversible biological Birch reduction at an extremely low redox potential”. J. Am. Chem. Soc. 132: 9850—9856. PMID 20578740.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Benzoyl-CoA+reductase на US National Library of Medicine Medical Subject Headings (MeSH)
