DDR2 (gen)

DDR2, ili CD167b (klaster diferencijacije 167b), je ljudski gen , koji je član broj 2 familije diskoidin domen receptora.

Diskoidin domen receptor familija, izoforma 2
Identifikatori
Simboli	DDR2; MIG20a; NTRKR3; TKT; TYRO10
Vanjski ID	OMIM: 191311 MGI: 1345277 HomoloGene: 68505 GeneCards: DDR2 Gene
Ontologija gena Molekularna funkcija • nukleotidno vezivanje • aktivnost protein-tirozin kinaze • aktivnost trasmembranskog protein tirozin kinaza receptora • receptorska aktivnost • ATP vezivanje • aktivnost transferaze Celularna komponenta • integralno sa membranom plazme • membrana Biološki proces • fosforilacija proteinskih aminokiselina • ćelijska adhezija • transdukcija signala • transmebranski receptor protein tirozin kinaza signalni put • pozitivna regulacija ćelijske proliferacije
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	4921	18214
Ensembl	ENSG00000162733	ENSMUSG00000026674
UniProt	Q16832	Q62371
RefSeq (mRNA)	NM_001014796	NM_022563
RefSeq (protein)	NP_001014796	NP_072075
Lokacija (UCSC)	Chr 1: 160.87 - 161.02 Mb	Chr 1: 171.81 - 171.95 Mb
PubMed pretraga	[1]	[2]

Receptor tirozin kinaze (RTK) igraju ključnu ulogu u komunikaciji ćelija sa njihovim mikro okruženjem. Ti molekuli su vezani za regulaciju ćelijskog rasta, diferencijacije i metabolizma. U više slučajeva biohemijski mehanizam kojim RTK sprovodi signal kroz membranu je pokazan da se sastoji od ligand indukovane oligomerizacije receptora, i naknadne intracelularna fosforilacije. Ova autofosforilacija dovodi do naknadne fosforilacije citosolnih proteina, kao i do asocijacije sa drugim molekulima koji su vezani za pleiotropske efekte transdukcije signala. RTK proteini imaju trojnu strukturu koja se sastoji od ekstracelularnog, transmembranskog, i citoplazmatičnog regiona. Ovaj gen kodira pripadnika nove RTK podklase sa različitim ekstracelularnim regionom koji okružuje domen sličan faktoru VIII. Alternativno spajanje (engl. splicing) ovog gena na 5' UTR dovodi do nekoliko transkript varijanti.

Interakcije

Demonstrirano je da DDR2 ima protein-protein interakciju sa SHC1.

Literatura

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