Diguanilat ciklaza
Diguanilat ciklaza (EC 2.7.7.65, DGC, PleD) je enzim sa sistematskim imenom GTP:GTP guanililtransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Diguanilat ciklaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.7.7.65 | ||||||||
| CAS broj | 146316-82-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 GTP 2 difosfat + ciklična di-3',5'-guanilat
Ovaj protein sadrži GGDEF-domen. Za njegov rad je neophodan jon Mg2+ ili Mn2+.
Reference уреди
- ^ Ryjenkov, D.A., Tarutina, M., Moskvin, O.V. and Gomelsky, M. (2005). „Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain”. J. Bacteriol. 187: 1792—1798. PMID 15716451.
- ^ Méndez-Ortiz, M.M., Hyodo, M., Hayakawa, Y. and Membrillo-Hernández, J. (2006). „Genome-wide transcriptional profile of Escherichia coli in response to high levels of the second messenger 3′,5′-cyclic diguanylic acid”. J. Biol. Chem. 281: 8090—8099. PMID 16418169.
- ^ Paul, R., Abel, S., Wassmann, P., Beck, A., Heerklotz, H. and Jenal, U. (2007). „Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization”. J. Biol. Chem. 282: 29170—29177. PMID 17640875.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Diguanylate+cyclase на US National Library of Medicine Medical Subject Headings (MeSH)
