EGLU
(2S)-α-Etilglutaminska kiselina (EGLU) je lek koji se koristi u neurološkim istraživanjima. On je bio jedno od prvih jedinjenja za koja je utvrđeno da deluju kao selektivni antagonisti za grupu II metabotropnih glutamatnih receptora (mGluR2/3), tako da je bio koristan u karakterizaciji i istraživanju ove receptorske familije.[1][2][3][4][5][6][7]
 | |
| IUPAC ime | |
|---|---|
(2S)-2-amino-2-etilpentandionska kiselina | |
| Identifikatori | |
| ATC kod | none |
| PubChem | CID 5311079 |
| IUPHAR/BPS | 1400 |
| Hemijski podaci | |
| Formula | C7H13NO4 |
| Molarna masa | 175,182 g/mol |
Reference уреди
- ^ Jane, DE; Thomas, NK; Tse, HW; Watkins, JC (1996). „Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord”. Neuropharmacology. 35 (8): 1029—35. PMID 9121605. doi:10.1016/S0028-3908(96)00048-2.
- ^ Huang, L; Rowan, MJ; Anwyl, R (1999). „Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro”. European Journal of Pharmacology. 366 (2–3): 151—8. PMID 10082195. doi:10.1016/S0014-2999(98)00918-2.
- ^ Palazzo, E; Marabese, I; De Novellis, V; Oliva, P; Rossi, F; Berrino, L; Rossi, F; Maione, S (2001). „Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception”. Neuropharmacology. 40 (3): 319—26. PMID 11166324. doi:10.1016/S0028-3908(00)00160-X.
- ^ Iserhot, C; Gebhardt, C; Schmitz, D; Heinemann, U (2004). „Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat”. Brain Research. 1027 (1–2): 151—60. PMID 15494166. doi:10.1016/j.brainres.2004.08.052.
- ^ Cahusac, PM; Wan, H (2007). „Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo”. Neuroscience. 146 (1): 202—12. PMID 17346894. doi:10.1016/j.neuroscience.2007.01.049.
- ^ Kim, WY; Vezina, P; Kim, JH (2008). „Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment”. Behavioural Brain Research. 191 (1): 62—6. PMID 18433894. doi:10.1016/j.bbr.2008.03.010.
- ^ Altinbilek, B; Manahan-Vaughan, D (2009). „A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory”. Neuroscience. 158 (1): 149—58. PMID 18722513. doi:10.1016/j.neuroscience.2008.07.045.
