GPR6
GPR6, G protein-spregnuti receptor 6, je protein koji je kod čoveka kodiran GPR6 genom.[1][2]
| G protein-spregnuti receptor 6 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | GPR6; | ||||||||||
| Vanjski ID | OMIM: 600553 MGI: 2155249 HomoloGene: 38026 IUPHAR: GPR6 GeneCards: GPR6 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2830 | 140741 | |||||||||
| Ensembl | ENSG00000146360 | ENSMUSG00000046922 | |||||||||
| UniProt | P46095 | Q2M2N8 | |||||||||
| RefSeq (mRNA) | NM_005284 | NM_199058 | |||||||||
| RefSeq (protein) | NP_005275 | NP_951013 | |||||||||
| Lokacija (UCSC) |
Chr 6: 110.41 - 110.41 Mb |
Chr 10: 40.76 - 40.76 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Funkcija уреди
GPR6 je član familije GPCR transmembranskih receptora. Postoje tvrdnje da je GPR6 konstitutivno aktivan, i da se dodatno aktivira sfingozin-1-fosfatom.[3]
GPR6 povišava nivoe cikličnog AMP i promoviše rast neurita.[4]
Vidi još уреди
Literatura уреди
- ^ „Entrez Gene: GPR6 G protein-coupled receptor 6”.
- ^ Song ZH, Modi W, Bonner TI (1995). „Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors”. Genomics. 28 (2): 347—9. PMID 8530049. doi:10.1006/geno.1995.1154.
- ^ Uhlenbrock K, Gassenhuber H, Kostenis E (2002). „Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors”. Cellular Signalling. 14 (11): 941—53. PMID 12220620. doi:10.1016/S0898-6568(02)00041-4.
- ^ Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (2007). „Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth”. The Journal of Biological Chemistry. 282 (14): 10506—15. PMID 17284443. doi:10.1074/jbc.M700911200.
Dodatna literatura уреди
- Heiber M; Docherty JM; Shah G; et al. (1995). „Isolation of three novel human genes encoding G protein-coupled receptors.”. DNA Cell Biol. 14 (1): 25—35. PMID 7832990. doi:10.1089/dna.1995.14.25.
- Song ZH, Modi W, Bonner TI (1996). „Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.”. Genomics. 28 (2): 347—9. PMID 8530049. doi:10.1006/geno.1995.1154.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Uhlenbrock K; Huber J; Ardati A; et al. (2003). „Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.”. Cell. Physiol. Biochem. 13 (2): 75—84. PMID 12649592. doi:10.1159/000070251.
- Mungall AJ; Palmer SA; Sims SK; et al. (2003). „The DNA sequence and analysis of human chromosome 6.”. Nature. 425 (6960): 805—11. PMID 14574404. doi:10.1038/nature02055.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
