Glicerofosfolipid aciltransferaza (KoA-zavisna)
Glicerofosfolipid aciltransferaza (KoA-zavisna) (EC 2.3.1.148) je enzim sa sistematskim imenom 1-organil-2-acil-sn-glicero-3-fosfoholin:1-organil-2-lizo-sn-glicero-3-fosfoetanolamin aciltransferaza (KoA-zavisna).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glicerofosfolipid aciltransferaza (KoA-zavisna) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.148 | ||||||||
| CAS broj | 9054-54-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 1-organil-2-acil-sn-glicero-3-fosfoholin + 1-organil-2-lizo-sn-glicero-3-fosfoeetanolamin 1-organil-2-acil-sn-glicero-3-fosfoeetanolamin + 1-organil-2-lizo-sn-glicero-3-fosfoholin
Ovaj enzim katalizuje transfer arahidonata i drugih polienoinskih masnih kiselina sa glicerofosfolipida koji sadrže holin ili etanolamin na sn-2 poziciju lizo-glicerofosfolipida.
Reference уреди
- ^ Irvine, R.F., Dawson, R.M.C. (1979). „Transfer of arachidonic acid between phospholipids in rat liver microsomes”. Biochem. Biophys. Res. Commun. 91: 1399—1405. PMID 526311.
- ^ Robinson, M., Blank, M.L., Snyder, F. (1985). „Acylation of lysophospholipids by rabbit alveolar macrophages. Specific CoA-dependent and CoA-independent reactions”. J. Biol. Chem. 260: 7889—7895. PMID 4008481.
- ^ Snyder, F., Lee, T.C., Blank, M.L. (1992). „The role of transacylases in the metabolism of arachidonate and platelet-activating factor”. Prog. Lipid Res. 31: 65—86. PMID 1641397.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Glycerophospholipid+acyltransferase+(CoA-dependent) на US National Library of Medicine Medical Subject Headings (MeSH)
