HMG-CoA reduktaza

hydroxymethylglutaryl-CoA reduktaza
hydroxymethylglutaryl-CoA reduktaza
Identifikatori
EC broj	1.1.1.88
CAS broj	37250-24-1
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Ontologija gena	AmiGO / EGO
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

HMG-CoA reduktaza
HMG-CoA reduktaza
EC broj	{{{EC_number}}}
Ontologija gena	AmiGO / EGO

3-hidroksi-3-metilglutaril-CoA reduktaza
3-hidroksi-3-metilglutaril-CoA reduktaza
	PDB prikaz baziran na 1dq8.
Dostupne strukture
	1DQ8, 1DQ9, 1DQA, 1HW8, 1HW9, 1HWI, 1HWJ, 1HWK, 1HWL, 2Q1L, 2Q6B, 2Q6C, 2R4F, 3BGL, 3CCT, 3CCW, 3CCZ, 3CD0, 3CD5, 3CD7, 3CDA, 3CDB
Identifikatori
Simboli	HMGCR; LDLCQ3
Vanjski ID	OMIM: 142910 MGI: 96159 HomoloGene: 30994 GeneCards: HMGCR Gene
EC broj	1.1.1.34
Ontologija gena
Molekularna funkcija	• aktivnost hidroksimetilglutaril-CoA reduktaze (NADPH); • aktivnost hidroksimetilglutaril-CoA reduktaze; • aktivnost proteinske homodimerizacije; • vezivanje koenzima; • NADPH vezivanje;
Celularna komponenta	• peroksizomalna membrana; • endoplazmatični retikulum; • membrana endoplazmatičnog retikuluma; • integralno sa membranom;
Biološki proces	• proces holesterolne biosinteze; • starenje; • respons na nutrijent; • proces izoprenoidne biosinteze;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	3156
Ensembl	ENSG00000113161
UniProt	P04035
RefSeq (mRNA)	NM_000859.2
RefSeq (protein)	NP_000850.1
Lokacija (UCSC)	Chr 5:; 74.63 - 74.66 Mb
PubMed pretraga	[1]

HMG-CoA reduktaza (3-hidroksi-3-metil-glutaril-CoA reduktaza, HMGCR) je enzim (EC 1.1.1.88) koji ograničava brzinu mevalonatnog puta, metaboličkog puta koji proizvodi holesterol i druge izoprenoide. Normalno je u ćelijama sisara ovaj enzim supresovan holesterolom koji potiče iz internalizacije i degradacije lipoproteina niske gustine (LDL) putem LDL receptora, kao i oksidovanim vrstama holesterola. Kompetitivni inhibitori reduktaze indukuju izražavanje LDL receptora u jeri, čime se povećava katabolizam LDL-a u plazmi, te se snižava koncentracija holesterola u plazmi, što je važna odrednica ateroskleroze.^[1]

Ovaj enzim je biološka meta široko dostupnih lekova za snižavanje nivoa holesterola, kolektivno poznatih kao statini. HMG-CoA reduktaza ze vezana za membranu endoplazmatičnog retikuluma, i dugo se mislilo da ima sedam transmembranskih domena, sa aktivnim mestom lociranim na njenom dugačkom karboksilnom domenu u citozolu. Nedavni nalazi su pokazali da sadrži osam transmembranskih domena.^[2]

Reference уреди

^ „Entrez Gene: HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase”.
^ Roitelman J, Olender EH, Bar-Nun S, Dunn WA, Simoni RD (1992). „Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum”. J. Cell Biol. 117 (5): 959—73. PMC 2289486  . PMID 1374417. doi:10.1083/jcb.117.5.959.

Literatura уреди

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Honda A; Salen G; Honda M; et al. (2000). „3-Hydroxy-3-methylglutaryl-coenzyme A reductase activity is inhibited by cholesterol and up-regulated by sitosterol in sitosterolemic fibroblasts”. J. Lab. Clin. Med. 135 (2): 174—9. PMID 10695663. doi:10.1067/mlc.2000.104459.
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Vidi još уреди

Oksidoreduktaza

Spoljašnje veze уреди

Cholesterol Synthesis Архивирано на сајту Wayback Machine (4. јул 2017) - has some good regulatory details
Proteopedia HMG-CoA_Reductase - the HMG-CoA Reductase Structure in Interactive 3D

[entrez-1] „Entrez Gene: HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase”.

[pmid1374417-2] Roitelman J, Olender EH, Bar-Nun S, Dunn WA, Simoni RD (1992). „Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum”. J. Cell Biol. 117 (5): 959—73. PMC 2289486  . PMID 1374417. doi:10.1083/jcb.117.5.959.

[1]

[2]