Hijaluronatna lijaza
Hijaluronatna lijaza (EC 4.2.2.1, hijaluronidaza, glukuronaglikozaminoglikanska lijaza, mukinaza) je enzim sa sistematskim imenom hialuronat lijaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hijaluronatna lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.2.1 | ||||||||
| CAS broj | 37259-53-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Razlaže hijaluronatne lance na beta-D-GalNAc-(1->4)-beta-D-GlcA vezi, čime se polisaharid razlaže do 3-(4-dezoksi-beta-D-gluk-4-enuronozil)-N-acetil-D-glukozamina
Ovaj enzim takođe deluje na hondroitin.
Reference уреди
- ^ Linker, A., Hoffman, P., Meyer, K., Sampson, P. and Korn, E.D. (1960). „The formation of unsaturated disacharides from mucopoly-saccharides and their cleavage to α-keto acid by bacterial enzymes”. J. Biol. Chem. 235: 3061—3061. PMID 13762462.
- ^ Meyer, K. & Rapport, M.M. (1952). „Hyaluronidases”. Adv. Enzymol. Relat. Subj. Biochem. 13: 199—236. PMID 14943668.
- ^ Moran, F., Nasuno, S. and Starr, M.P. (1968). „Extracellular and intracellular polygalacturonic acid trans-eliminases of Erwinia carotovora”. Arch. Biochem. Biophys. 123: 298—306. PMID 5642600.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Hyaluronate+lyase на US National Library of Medicine Medical Subject Headings (MeSH)
