Hondroitinska AC lijaza
Hondroitinska AC lijaza (EC 4.2.2.5, hondroitinaza, hondroitin sulfatna lijaza, hondroitin AC eliminaza, hondroitinaza AC, ChnAC) je enzim sa sistematskim imenom hondroitin AC lijaza.[1][2][3][3][4][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hondroitinska AC lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.2.5 | ||||||||
| CAS broj | 9047-57-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Eliminativna degradacija polisaharida koji sadrže 1,4-beta-D-heksozaminil i 1,3-beta-D-glukuronazil veze do disaharida koji sadrže 4-dezoksi-beta-D-gluk-4-enuronozil grupe
Ovaj enzim deluje na hondroitin 4-sulfat i hondroitin 6-sulfat.
Reference уреди
- ^ Nakada, H.I. & Wolfe, J.B. (1961). „Studies on the enzyme chondroitinase: product structure and ion effects”. Arch. Biochem. Biophys. 94: 244—251. PMID 13727579.
- ^ Pojasek, K., Shriver, Z., Kiley, P., Venkataraman, G. and Sasisekharan, R. (2001). „Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum”. Biochem. Biophys. Res. Commun. 286: 343—351. PMID 11500043.
- ^ а б Fethiere, J., Shilton, B.H., Li, Y., Allaire, M., Laliberte, M., Eggimann, B. and Cygler, M. (1998). „Crystallization and preliminary analysis of chondroitinase AC from Flavobacterium heparinum”. Acta Crystallogr. D Biol. Crystallogr. 54: 279—280. PMID 9761894.
- ^ а б Huckerby, T.N., Nieduszynski, I.A., Giannopoulos, M., Weeks, S.D., Sadler, I.H. and Lauder, R.M. (2005). „Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides”. FEBS J. 272: 6276—6286. PMID 16336265.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Chondroitin+AC+lyase на US National Library of Medicine Medical Subject Headings (MeSH)
