IRNK guanililtransferaza
(преусмерено са IRNK završavajući enzim)
IRNK guanililtransferaza (EC 2.7.7.50, iRNK završavajući enzim, informaciona RNK guanililtransferaza, protein lambda 2) je enzim sa sistematskim imenom GTP:iRNK guanililtransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| IRNK guanililtransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.7.50 | ||||||||
| CAS broj | 56941-23-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- GTP + (5')ppPur-iRNK difosfat + G(5')pppPur-iRNK
Ovaj enzim takođe može da modifikuje sintetički poli(A) i poli(G) čime formira strukture m7G(5')pppAn i m7G(5')pppGn.
Reference уреди
- ^ Ensinger, M.J., Martin, S.A., Paoletti, E. and Moss, B. (1975). „Modification of the 5′-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus”. Proc. Natl. Acad. Sci. USA. 72: 2525—2529. PMID 1058472.
- ^ Groner, Y., Gilbao, E. and Aviv, H. (1978). „Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates”. Biochemistry. 17: 977—982. PMID 629955.
- ^ Itoh, N., Yamada, H., Kaziro, Y. and Mizumoto, K. (1987). „Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. Large scale purification, subunit functions, and subcellular localization”. J. Biol. Chem. 262: 1989—1995. PMID 3029058.
- ^ Martin, S.A. & Moss, B. (1975). „Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7)methyltransferase from vaccinia virions”. J. Biol. Chem. 250: 9330—9335. PMID 1194287.
- ^ Martin, S.A., Paoletti, E. and Moss, B. (1975). „Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions”. J. Biol. Chem. 250: 9322—9329. PMID 1194286.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- MRNA+guanylyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
