Jodid peroksidaza
Jodid peroksidaza (EC 1.11.1.8, tiroidna peroksidaza, jodotirozinska dejodaza, jodinaza, jodoperoksidaza (hem tip), jodidna peroksidaza-tirozinska jodinaza, jodotirozinska dejodinaza, monojodotirozinska dejodinaza, tiroperoksidaza, tirozinska jodinaza, TPO) je enzim sa sistematskim imenom jod:vodonik-peroksid oksidoreduktaza.[1][2][3][4][5][6][7][8][9][10][11] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Jodid peroksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.11.1.8 | ||||||||
| CAS broj | 9031-28-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) 2 jodid + H2O2 + 2 H+ dijodin + 2H2O
- (2) [tiroglobulin]-L-tirozin + jodid + H2O2 [tiroglobulin]-3-jodo-L-tirozin + 2H2O
- (3) [tiroglobulin]-3-jodo-L-tirozin + jodid + H2O2 [tiroglobulin]-3,5-dijodo-L-tirozin + 2H2O
- (4) 2 [tiroglobulin]-3,5-dijodo-L-tirozin + H2O2 [tiroglobulin]-L-tiroksin + [tiroglobulin]-aminoakrilat + 2H2O
- (5) [tiroglobulin]-3-jodo-L-tirozin + [tiroglobulin]-3,5-dijodo-L-tirozin + H2O2 [tiroglobulin]-3,5,3'-trijodo-L-tironin + [tiroglobulin]-aminoakrilat + 2H2O
Tiroidna peroksidaza katalizuje biosintezu tiroidnih hormona L-tiroksina i trijodo-L-tironina.
Reference уреди
- ^ Cunningham, B.A. & Kirkwood, S. (1961). „Enzyme systems concerned with the synthesis of monoiodotyrosine. III. Ion requirements of the soluble system”. J. Biol. Chem. 236: 485—489. PMID 13718859.
- ^ Hosoya, T., Kondo, Y. and Ui, N. (1962). „Peroxidase activity in thyroid gland and partial purification of the enzyme”. J. Biochem. (Tokyo). 52: 180—189. PMID 13964156.
- ^ Coval, M.L. & Taurog, A. (1967). „Purification and iodinating activity of hog thyroid peroxidase”. J. Biol. Chem. 242: 5510—5523. PMID 12325367.
- ^ Gavaret, J.M., Cahnmann, H.J. and Nunez, J. (1981). „Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction”. J. Biol. Chem. 256: 9167—9173. PMID 7021557.
- ^ Ohtaki, S., Nakagawa, H., Nakamura, M. and Yamazaki, I. (1982). „One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase”. J. Biol. Chem. 257: 13398—13403. PMID 7142155.
- ^ Magnusson, R.P., Taurog, A. and Dorris, M.L. (1984). „Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase”. J. Biol. Chem. 259: 197—205. PMID 6706930.
- ^ Virion, A., Courtin, F., Deme, D., Michot, J.L., Kaniewski, J. and Pommier, J. (1985). „Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions”. Arch. Biochem. Biophys. 242: 41—47. PMID 2996435.
- ^ Rawitch, A.B., Pollock, G., Yang, S.X. and Taurog, A. (1992). „Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase”. Arch. Biochem. Biophys. 297: 321—327. PMID 1497352.
- ^ Sun, W. & Dunford, H.B. (1993). „Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine”. Biochemistry. 32: 1324—1331. PMID 8448141.
- ^ Taurog, A., Dorris, M.L. and Doerge, D.R. (1996). „Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase”. Arch. Biochem. Biophys. 330: 24—32. PMID 8651700.
- ^ Ruf, J. & Carayon, P. (2006). „Structural and functional aspects of thyroid peroxidase”. Arch. Biochem. Biophys. 445: 269—277. PMID 16098474.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Iodide+peroxidase на US National Library of Medicine Medical Subject Headings (MeSH)
