L-treonin 3-dehidrogenaza
L-treonin 3-dehidrogenaza (EC 1.1.1.103, L-treoninska dehidrogenaza, treoninska 3-dehidrogenaza, treoninska dehidrogenaza, TDH) je enzim sa sistematskim imenom L-treonin:NAD+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| L-treonin 3-dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.103 | ||||||||
| CAS broj | 9067-99-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-treonin + NAD+ L-2-amino-3-oksobutanoat + NADH + H+
L-treoninska 3-dehidrogenaza deluje zajedno sa EC 2.3.1.29, glicinskom C-acetiltransferazom, u degradaciji treonina do glicina. Ovaj put treoninske degradacije je uobičajen za prokariotske i eukariotske ćelije. Ova dva enzima formiraju kompleks. U vodenom rastvoru se produkt, L-2-amino-3-oksobutanoat, može spontano dekarboksilisati, čime se formira aminoaceton.
Reference уреди
- ^ Green, M.L. & Elliott, W.H. (1964). „The enzymic formation of aminoacetone from threonine and its further metabolism”. Biochem. J. 92: 537—549. PMID 4284408.
- ^ Hartshorne, D. & Greenberg, D.M. (1964). „Studies on liver threonine dehydrogenase”. Arch. Biochem. Biophys. 105: 173—178. PMID 14165492.
- ^ Newman, E.B., Kapoor, V. and Potter, R. (1976). „Role of L-threonine dehydrogenase in the catabolism of threonine and synthesis of glycine by Escherichia coli”. J. Bacteriol. 126: 1245—1249. PMID 7548.
- ^ Epperly, B.R. & Dekker, E.E. (1991). „L-Threonine dehydrogenase from Escherichia coli. Identification of an active site cysteine residue and metal ion studies”. J. Biol. Chem. 266: 6086—6092. PMID 2007567.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- L-threonine+3-dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
