Lipid IVA 4-amino-4-dezoksi-L-arabinoziltransferaza

Lipid IVA 4-amino-4-dezoksi-L-arabinoziltransferaza (EC 2.4.2.43, undekaprenil fosfat-alfa-L-Ara4N transferaza, 4-amino-4-dezoksi-L-arabinoza lipid A transferaza, protein polimiksinske otpornosti PmrK, arnT (gen)) je enzim sa sistematskim imenom 4-amino-4-dezoksi-alfa-L-arabinopiranozil ditran,oktacis-undekaprenil fosfat:lipid IVA 4-amino-4-dezoksi-L-arabinopiranosiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Lipid IVA 4-amino-4-dezoksi-L-arabinoziltransferaza
Identifikatori
EC broj2.4.2.43
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
(1) 4-amino-4-dezoksi-alfa-L-arabinopiranozil ditrans,oktacis-undekaprenil fosfat + alfa-Kdo-(2->4)-alfa-Kdo-(2->6)-lipid A alfa-Kdo-(2->4)-alfa-Kdo-(2->6)-[4-P-L-Ara4N]-lipid A + ditrans,oktacis-undekaprenil fosfat
(2) 4-amino-4-dezoksi-alfa-L-arabinopiranozil ditrans,oktacis-undekaprenil fosfat + lipid IVA lipid IIA + ditrans,oktacis-undekaprenil fosfat
(3) 4-amino-4-dezoksi-alfa-L-arabinopiranozil ditrans,oktacis-undekaprenil fosfat + alfa-Kdo-(2->4)-alfa-Kdo-(2->6)-lipid IVA 4'-alfa-L-Ara4N-alfa-Kdo-(2->4)-alfa-Kdo-(2->6)-lipid IVA + ditrans,oktacis-undekaprenil fosfat

Ovaj integralni membranski protein je prisutan na unutrašnjim membranama pojedinih Gram negativnih endobakterija.

Reference уреди

  1. ^ Trent, M.S., Ribeiro, A.A., Lin, S., Cotter, R.J. and Raetz, C.R. (2001). „An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor”. J. Biol. Chem. 276: 43122—43131. PMID 11535604. 
  2. ^ Trent, M.S., Ribeiro, A.A., Doerrler, W.T., Lin, S., Cotter, R.J. and Raetz, C.R. (2001). „Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm”. J. Biol. Chem. 276: 43132—43144. PMID 11535605. 
  3. ^ Zhou, Z., Ribeiro, A.A., Lin, S., Cotter, R.J., Miller, S.I. and Raetz, C.R. (2001). „Lipid A modifications in polymyxin-resistant Salmonella typhimurium: PMRA-dependent 4-amino-4-deoxy-L-arabinose, and phosphoethanolamine incorporation”. J. Biol. Chem. 276: 43111—43121. PMID 11535603. 
  4. ^ Bretscher, L.E., Morrell, M.T., Funk, A.L. and Klug, C.S. (2006). „Purification and characterization of the L-Ara4N transferase protein ArnT from Salmonella typhimurium”. Protein Expr. Purif. 46: 33—39. PMID 16226890. 
  5. ^ Impellitteri, N.A., Merten, J.A., Bretscher, L.E. and Klug, C.S. (2010). „Identification of a functionally important loop in Salmonella typhimurium ArnT”. Biochemistry. 49: 29—35. PMID 19947657. 

Literatura уреди

Spoljašnje veze уреди