Manitol dehidrogenaza
Manitol dehidrogenaza (EC 1.1.1.255, MTD, NAD+-zavisni manitol dehidrogenaza) je enzim sa sistematskim imenom manitol:NAD+ 1-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Manitol dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.255 | ||||||||
| CAS broj | 144941-29-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- D-manitol + NAD+ D-manoza + NADH + H+
Ovaj enzim iz Apium graveolens]] (celera) oksiduje alditole sa minimalnim zahtevom za 2R hiralnost ugljenika susednog primarnom ugljeniku koji podleže oksidaciji. Ovaj enzim je specifičan za NAD+ i ne koristi NADP+.
Reference уреди
- ^ Stoop, J.M.H. & Pharr, D.M. (1992). „Partial purification and characterization of mannitol: mannose 1-oxidoreductase from celeriac (Apium graveolens var. rapaceum) roots”. Arch. Biochem. Biophys. 298: 612—619. PMID 1416989.
- ^ Stoop, J.M.H., Williamson, J.D., Conkling, M.A. and Pharr, D.M. (1995). „Purification of NAD-dependent mannitol dehydrogenase from celery suspension cultures”. Plant Physiol. (1995). 108: 1219—1225. PMID 7630943.
- ^ Williamson, J.D., Stoop, J.M.H., Massel, M.O., Conkling, M.A. and Pharr, D.M. (1995). „Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3”. Proc. Natl. Acad. Sci. USA. 92: 7148—7152. PMID 7638158.
- ^ Stoop, J.M.H., Chilton, W.S. and Pharr, D.M. (1996). „Substrate specificity of the NAD-dependent mannitol dehydrogenase from celery”. Phytochemistry. 43: 1145—1150.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Mannitol+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
