Википедија

Mepakrin

Mepakrin je organsko jedinjenje, koje sadrži 23 atoma ugljenika i ima molekulsku masu od 399,957 Da.[1][2][3][4][5][6][7]

Mepakrin
Klinički podaci
Prodajno imeAcrichine, Acrinamine, Acriquine, Akrichin
Drugs.comMonografija
Farmakokinetički podaci
Poluvreme eliminacije5 - 14 dana
Identifikatori
CAS broj83-89-6 ДаY
ATC kodNone
PubChemCID 237
DrugBankDB01103 ДаY
ChemSpider232 ДаY
KEGGC07339 ДаY
ChEBICHEBI:8711 ДаY
ChEMBLCHEMBL7568 ДаY
Hemijski podaci
FormulaC23H30ClN3O
Molarna masa399,957
  • CCN(CC)CCCC(C)NC1=C2C=C(OC)C=CC2=NC2=C1C=CC(Cl)=C2
  • InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) ДаY
  • Key:GPKJTRJOBQGKQK-UHFFFAOYSA-N ДаY
Fizički podaci
Tačka topljenja248—250 °C (478—482 °F)

Osobine уреди

Osobina Vrednost
Broj akceptora vodonika 4
Broj donora vodonika 1
Broj rotacionih veza 9
Particioni koeficijent[8] (ALogP) 5,7
Rastvorljivost[9] (logS, log(mol/L)) -7,6
Polarna površina[10] (PSA, Å2) 37,4

Reference уреди

  1. ^ Canete, R.; Escobedo, A. A.; Gonzalez, M. E.; Almirall, P. (2006). „Randomized clinical study of five days apostrophe therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children”. World Journal of Gastroenterology. 12 (39): 6366—70. PMC 4088148  . PMID 17072963. doi:10.3748/wjg.v12.i39.6366. 
  2. ^ Toubi, E.; Kessel, A.; Rosner, I.; Rozenbaum, M.; Paran, D.; Shoenfeld, Y. (2006). „The reduction of serum B-lymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus”. 2006 Apr. 63 (4): 299—303. PMID 16623930. S2CID 40984831. doi:10.1111/j.1365-3083.2006.01737.x. 
  3. ^ -{Zipper J, Cole LP, Goldsmith A, Wheeler R, Rivera M: Quinacrine hydrochloride pellets: preliminary data on a nonsurgical method of female sterilization. Int J Gynaecol Obstet. Zipper, J.; Cole, L. P.; Goldsmith, A.; Wheeler, R.; Rivera, M. (1980). „Quinacrine hydrochloride pellets: Preliminary data on a nonsurgical method of female sterilization”. 1980. 18 (4): 275—9. PMID 6109672. S2CID 41946631. doi:10.1002/j.1879-3479.1980.tb00496.x. 
  4. ^ Bhatt, R. V. (1991). „Camp laparoscopic sterilization deaths in Gujarat State, India, 1978-1980”. 1991 Dec. 17 (4): 297—301. PMID 1839351. doi:10.1111/j.1447-0756.1991.tb00277.x. 
  5. ^ -{Peterson HB, Lubell I, DeStefano F, Ory HW: The safety and efficacy of tubal sterilization: an international overview. Int J Gynaecol Obstet. Peterson, H.B.; Lubell, I.; Destefano, F.; Ory, H.W. (1983). „The safety and efficacy of tubal sterilization: An international overview”. 1983 Apr. 21 (2): 139—44. PMID 6136433. S2CID 15179539. doi:10.1016/0020-7292(83)90051-6. 
  6. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709  . PMID 21059682. doi:10.1093/nar/gkq1126. 
  7. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889  . PMID 18048412. doi:10.1093/nar/gkm958. 
  8. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  9. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  10. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura уреди

Spoljašnje veze уреди

 
Mepakrin na Vikimedijinoj ostavi.
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