Mikocerosat sintaza
Mikocerosat sintaza (EC 2.3.1.111, sintaza mikocerozinske kiseline) je enzim sa sistematskim imenom acil-KoA:metilmalonil-KoA C-aciltransferaza (dekarboksilacija, oksoacil- i enoil-redukcija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Mikocerosat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.111 | ||||||||
| CAS broj | 95229-19-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acil-KoA + n metilmalonil-KoA + 2n NADPH + 2n H+ multi-metil-branched acil-KoA + n KoA + n CO2 + 2n NADP+
Ovaj enzim produžava KoA estre masnih kiseline od C6 do C20 inkorporacijom metilmalonilnih ostataka, čime se formiraju multimetil-razgranate masna-acil-KoA kao što je 2,4,6,8-tetrametil-oktanoil-KoA.
Reference
уреди- ^ Rainwater, D.L. & Kollattukudy, P.E. (1985). „Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guérin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA”. J. Biol. Chem. 260: 616—623. PMID 3880746.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Mycocerosate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
