Mikrozomalna epoksidna hidrolaza
Mikrozomalna epoksidna hidrolaza (EC 3.3.2.9, epoksidna hidrataza, mikrozomalno epoksidna hidrataza, epoksidna hidraza, mikrozomalno epoksidna hidraza, aren-oksidna hidrataza, benzo(a)piren-4,5-oksidna hidrataza, benzo(a)piren-4,5-epoksidna hidrataza, aril epoksidna hidraza, cis-epoksidna hidrolaza, mEH) je enzim sa sistematskim imenom cis-stilben-oksidna hidrolaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Mikrozomalna epoksidna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.3.2.9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- cis-stilben oksid + H2O (+)-(1R,2R)-1,2-difeniletan-1,2-diol
Ovaj ključni hepatički enzim učestvuje u metabolizmu brojnih ksenobiotika, poput 1,3-butadien oksida, stiren oksida i policikličnnog aromatičnog ugljovodonika benzo[a]piren 4,5-oksida.
Reference уреди
- ^ Jakoby, W.B. & Fjellstedt, T.A. (1972). „Epoxidases”. Ур.: Boyer, P.D. The Enzymes. 7 (3rd изд.). New York: Academic Press. стр. 199—212.
- ^ Lu, A.Y., Ryan, D., Jerina, D.M., Daly, J.W. and Levin, W. (1975). „Liver microsomal expoxide hydrase. Solubilization, purification, and characterization”. J. Biol. Chem. 250: 8283—8288. PMID 240858.
- ^ Oesch, F. (1974). „Purification and specificity of a human microsomal epoxide hydratase”. Biochem. J. 139: 77—88. PMID 4463951.
- ^ Oesch, F. & Daly, J. (1971). „Solubilization, purification, and properties of a hepatic epoxide hydrase”. Biochim. Biophys. Acta. 227: 692—697. PMID 4998715.
- ^ Bellucci, G., Chiappe, C. and Ingrosso, G. (1994). „Kinetics and stereochemistry of the microsomal epoxide hydrolase-catalyzed hydrolysis of cis-stilbene oxides”. Chirality. 6: 577—582. PMID 7986671.
- ^ Morisseau, C. & Hammock, B.D. (2005). „Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles”. Annu. Rev. Pharmacol. Toxicol. 45: 311—333. PMID 15822179.
- ^ Fretland, A.J. & Omiecinski, C.J. (2000). „Epoxide hydrolases: biochemistry and molecular biology”. Chem. Biol. Interact. 129: 41—59. PMID 11154734.
- ^ Oesch, F. (1973). „Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds”. Xenobiotica. 3: 305—340. PMID 4584115.
- ^ Lacourciere, G.M. & Armstrong, R.N. (1994). „Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes”. Chem. Res. Toxicol. 7: 121—124. PMID 8199297.
- ^ Newman, J.W., Morisseau, C. and Hammock, B.D. (2005). „Epoxide hydrolases: their roles and interactions with lipid metabolism”. Prog. Lipid Res. 44: 1—51. PMID 15748653.
Литература уреди
- Jakoby, W.B. & Fjellstedt, T.A. (1972). „Epoxidases”. Ур.: Boyer, P.D. The Enzymes. 7 (3rd изд.). New York: Academic Press. стр. 199—212.
Spoljašnje veze уреди
- Microsomal+epoxide+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
