Norbinaltorfimin

Norbinaltorfimin
IUPAC ime
	17,17'-(dicyclopropylmethyl)-6,6',7,7'-6,6'-imino- 7,7'-binorphinan-3,4',14,14'-tetrol
Identifikatori
CAS broj	105618-26-6
ATC kod	none
PubChem	CID 3034416
IUPHAR/BPS	1642
Hemijski podaci
Formula	C40H43N3O6
Molarna masa	661.784 g/mol
	SMILES Oc5ccc4CC3N(CC12CC12)CCC711c4c5OC11c1nc9C6Oc8c(O)ccc(CC10C2(O)Cc9c1CC37O)c8C26CCN10CC13CC13; ;

Norbinaltorphimin (nor-BNI) je opioidni antagonist koji se koristi u naučnim istraživanjima. On je jedan od malobrojnih dostupnih opioidnih antagonista koji su visoko selektivni za κ-opioidni receptor, i blokiraju taj receptor bez uticaja na μ- ili δ-opioidni receptor.^[1] although On je manje selektivan in vivo nego kad se koristi u izolovanim tkivima.^[2] nor-BNI blokira efekte kapa agonista u životinjskim modelima,^[3]^[4] i proizvodi antidepresantske efekte.^[5]

Vidi još уреди

JDTic

Reference уреди

^ Portoghese, P. S.; Lipkowski, A. W.; Takemori, A. E. (1987). „Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists”. Life Sciences. 40 (13): 1287—92. PMID 2882399. doi:10.1016/0024-3205(87)90585-6.
^ Birch, P. J.; Hayes, A. G.; Sheehan, M. J.; Tyers, M. B. (1987). „Norbinaltorphimine: Antagonist profile at kappa opioid receptors”. European Journal of Pharmacology. 144 (3): 405—8. PMID 2831070. doi:10.1016/0014-2999(87)90397-9. }-
^ Takemori, A. E.; Ho, B. Y.; Naeseth, J. S.; Portoghese, P. S. (1988). „Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays”. The Journal of Pharmacology and Experimental Therapeutics. 246 (1): 255—8. PMID 2839664.
^ Takemori, A. E.; Schwartz, M. M.; Portoghese, P. S. (1988). „Suppression by nor-binaltorphimine of kappa opioid-mediated diuresis in rats”. The Journal of Pharmacology and Experimental Therapeutics. 247 (3): 971—4. PMID 2849679.
^ Shirayama, Y.; Ishida, H.; Iwata, M.; Hazama, G. I.; Kawahara, R.; Duman, R. S. (2004). „Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects”. Journal of Neurochemistry. 90 (5): 1258—68. PMID 15312181. S2CID 24121205. doi:10.1111/j.1471-4159.2004.02589.x.

Spoljašnje veze уреди

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Portoghese, P. S.; Lipkowski, A. W.; Takemori, A. E. (1987). „Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists”. Life Sciences. 40 (13): 1287—92. PMID 2882399. doi:10.1016/0024-3205(87)90585-6.

[2] Birch, P. J.; Hayes, A. G.; Sheehan, M. J.; Tyers, M. B. (1987). „Norbinaltorphimine: Antagonist profile at kappa opioid receptors”. European Journal of Pharmacology. 144 (3): 405—8. PMID 2831070. doi:10.1016/0014-2999(87)90397-9. }-

[3] Takemori, A. E.; Ho, B. Y.; Naeseth, J. S.; Portoghese, P. S. (1988). „Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays”. The Journal of Pharmacology and Experimental Therapeutics. 246 (1): 255—8. PMID 2839664.

[4] Takemori, A. E.; Schwartz, M. M.; Portoghese, P. S. (1988). „Suppression by nor-binaltorphimine of kappa opioid-mediated diuresis in rats”. The Journal of Pharmacology and Experimental Therapeutics. 247 (3): 971—4. PMID 2849679.

[5] Shirayama, Y.; Ishida, H.; Iwata, M.; Hazama, G. I.; Kawahara, R.; Duman, R. S. (2004). „Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects”. Journal of Neurochemistry. 90 (5): 1258—68. PMID 15312181. S2CID 24121205. doi:10.1111/j.1471-4159.2004.02589.x.

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