Norbuprenorfin
Norbuprenorfin je primarni aktivni metabolit buprenorfina. Norbuprenorfin deluje kao pun agonist μ-opioidnog, δ-opioidnog, i nociceptinskog receptora,[1][2] kao i parcijalni agonist κ-opioidnog receptora.[2] Norbuprenorfin prolazi kroz krvno-moždanu barijeru slično buprenorfinu i verovatno doprinosi njegovom dejstvu.[3]
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| IUPAC ime | |
|---|---|
(5α,6β,14β,18R)-18-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol | |
| Identifikatori | |
| CAS broj | 78715-23-8  |
| ATC kod | none |
| PubChem | CID 6426801 |
| ChemSpider | 4932224 |
| Hemijski podaci | |
| Formula | C25H35NO4 |
| Molarna masa | 413.55 g/mol |
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Vidi još уреди
Literatura уреди
- ^ Yassen A, Kan J, Olofsen E, Suidgeest E, Dahan A, Danhof M (2007). „Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats”. The Journal of Pharmacology and Experimental Therapeutics. 321 (2): 598—607. PMID 17283225. doi:10.1124/jpet.106.115972.
- ^ а б Huang P, Kehner GB, Cowan A, Liu-Chen LY (2001). „Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist”. The Journal of Pharmacology and Experimental Therapeutics. 297 (2): 688—95. PMID 11303059.
- ^ Jensen ML, Foster D, Upton R, Grant C, Martinez A, Somogyi A (2007). „Comparison of cerebral pharmacokinetics of buprenorphine and norbuprenorphine in an in vivo sheep model”. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 37 (4): 441—57. PMID 17455115. doi:10.1080/00498250701251126.
Spoljašnje veze уреди
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
