Ornitin ciklodeaminaza
Ornitin ciklodeaminaza (EC 4.3.1.12, ornitinska ciklaza, ornitinska ciklaza (deaminacija), OCD) je enzim sa sistematskim imenom L-ornitin amonijak-lijaza (ciklizacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Ornitin ciklodeaminaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.3.1.12 | ||||||||
| CAS broj | 9054-76-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-ornitin L-prolin + NH3
Ovaj enzim je član mi-kristalinske proteinske familije. Reakciju stimuliše prisustvo ADP ili ATP, a inhibira je O2.
Reference уреди
- ^ Costilow, R.N. & Laycock, L. (1971). „Ornithine cyclase (deaminating). Purification of a protein that converts ornithine to proline and definition of the optimal assay conditions”. J. Biol. Chem. 246: 6655—6660. PMID 4399881.
- ^ Muth, W.L. & Costilow, R.N. (1974). „Ornithine cyclase (deaminating). II. Properties of the homogeneous enzyme”. J. Biol. Chem. 249: 7457—7462. PMID 4373469.
- ^ Espineda, C.E., Linford, A.S., Devine, D. and Brusslan, J.A. (1999). „The AtCAO gene, encoding chlorophyll a oxygenase, is required for chlorophyll b synthesis in Arabidopsis thaliana”. Proc. Natl. Acad. Sci. USA. 96: 10507—10511. PMID 10468639.
- ^ Goodman, J.L., Wang, S., Alam, S., Ruzicka, F.J., Frey, P.A. and Wedekind, J.E. (2004). „Ornithine cyclodeaminase: structure, mechanism of action, and implications for the μ-crystallin family”. Biochemistry. 43: 13883—13891. PMID 15518536.
- ^ Alam, S., Wang, S.C., Ruzicka, F.J., Frey, P.A. and Wedekind, J.E. (2004). „Crystallization and X-ray diffraction analysis of ornithine cyclodeaminase from Pseudomonas putida”. Acta Crystallogr. D Biol. Crystallogr. 60: 941—944. PMID 15103146.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Ornithine+cyclodeaminase на US National Library of Medicine Medical Subject Headings (MeSH)
