PD-168,077

PD-168,077
IUPAC ime
	N-([4-(2-cijanofenil)piperazin-1-il]metil)-3-metilbenzamid
Identifikatori
ATC kod	none
PubChem	CID 3645619
ChEMBL	CHEMBL45244
Hemijski podaci
Formula	C20H22N4O
Molarna masa	334,414 g/mol
	SMILES Cc2cc(ccc2)C(=O)NCN(CC3)CCN3c1ccccc1C#N; ;

PD-168,077 je lek koji deluje kao dopaminski agonist. On je selektivan za D₄ podtip,^[1]^[2] i koristi se za istraživanje uloge tog receptora u mozgu,^[3]^[4]^[5] posebno u pogledu njegove uloge u učenju i memoriji.^[6]

Reference уреди

^ Clifford JJ, Waddington JL (2000). „Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists”. Neuropsychopharmacology. 22 (5): 538—44. PMID 10731629. doi:10.1016/S0893-133X(99)00141-4.
^ Matulenko MA, Hakeem AA, Kolasa T, Nakane M, Terranova MA, Uchic ME, Miller LN, Chang R, Donnelly-Roberts DL, Namovic MT, Moreland RB, Brioni JD, Stewart AO (2004). „Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists”. Bioorganic & Medicinal Chemistry. 12 (13): 3471—83. PMID 15186832. doi:10.1016/j.bmc.2004.04.035.
^ Wang X, Zhong P, Gu Z, Yan Z (2003). „Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex”. Journal of Neuroscience. 23 (30): 9852—61. PMID 14586014.
^ Melis MR, Succu S, Sanna F, Melis T, Mascia MS, Enguehard-Gueiffier C, Hubner H, Gmeiner P, Gueiffier A, Argiolas A (2006). „PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain”. The European Journal of Neuroscience. 24 (7): 2021—30. PMID 17067298. doi:10.1111/j.1460-9568.2006.05043.x.
^ Succu S, Sanna F, Melis T, Boi A, Argiolas A, Melis MR (2007). „Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin”. Neuropharmacology. 52 (3): 1034—43. PMID 17164075. doi:10.1016/j.neuropharm.2006.10.019.
^ Bernaerts P, Tirelli E (2003). „Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice”. Behavioural Brain Research. 142 (1–2): 41—52. PMID 12798264. doi:10.1016/S0166-4328(02)00371-6.

Spoljašnje veze уреди

[pmid10731629-1] Clifford JJ, Waddington JL (2000). „Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists”. Neuropsychopharmacology. 22 (5): 538—44. PMID 10731629. doi:10.1016/S0893-133X(99)00141-4.

[pmid15186832-2] Matulenko MA, Hakeem AA, Kolasa T, Nakane M, Terranova MA, Uchic ME, Miller LN, Chang R, Donnelly-Roberts DL, Namovic MT, Moreland RB, Brioni JD, Stewart AO (2004). „Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists”. Bioorganic & Medicinal Chemistry. 12 (13): 3471—83. PMID 15186832. doi:10.1016/j.bmc.2004.04.035.

[pmid14586014-3] Wang X, Zhong P, Gu Z, Yan Z (2003). „Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex”. Journal of Neuroscience. 23 (30): 9852—61. PMID 14586014.

[pmid17067298-4] Melis MR, Succu S, Sanna F, Melis T, Mascia MS, Enguehard-Gueiffier C, Hubner H, Gmeiner P, Gueiffier A, Argiolas A (2006). „PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain”. The European Journal of Neuroscience. 24 (7): 2021—30. PMID 17067298. doi:10.1111/j.1460-9568.2006.05043.x.

[pmid17164075-5] Succu S, Sanna F, Melis T, Boi A, Argiolas A, Melis MR (2007). „Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin”. Neuropharmacology. 52 (3): 1034—43. PMID 17164075. doi:10.1016/j.neuropharm.2006.10.019.

[pmid12798264-6] Bernaerts P, Tirelli E (2003). „Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice”. Behavioural Brain Research. 142 (1–2): 41—52. PMID 12798264. doi:10.1016/S0166-4328(02)00371-6.

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