PEPA (lek)
PEPA je ampakinski lek koji deluje kao alosterni potencijator desenzitizacije AMPA receptora.[1][2] On je oko 100 puta potentniji od aniracetama in vitro.[3] It produces memory-enhancing effects in rats when administered intravenously.[4]
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| IUPAC ime | |
|---|---|
2-[2,6-difluoro-4-({2-[(fenilsulfonil)amino]etil}tio)fenoksi]acetamid | |
| Pravni status | |
| Pravni status |
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| Identifikatori | |
| CAS broj | 141286-78-4  |
| ATC kod | none |
| PubChem | CID 6603828 |
| Sinonimi | PEPA |
| Hemijski podaci | |
| Formula | C16H16F2N2O4S2 |
| Molarna masa | 402.436 g/mol |
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Reference уреди
- ^ Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, Kohsaka S, Wada K (1998). „Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures”. British Journal of Pharmacology. 123 (7): 1294—303. PMC 1565288
. PMID 9579722. doi:10.1038/sj.bjp.0701707.
- ^ Sekiguchi (2002). „A desensitization-selective potentiator of AMPA-type glutamate receptors”. British Journal of Pharmacology. 136 (7): 1033—41. PMC 1573432 . PMID 12145103. doi:10.1038/sj.bjp.0704804. Пронађени су сувишни параметри:
|author=и|last1=(помоћ) - ^ Sekiguchi, M; Fleck, MW; Mayer, ML; Takeo, J; Chiba, Y; Yamashita, S; Wada, K (1997). „A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide”. Journal of Neuroscience. 17 (15): 5760—71. PMID 9221774.
- ^ Sekiguchi, M; Yamada, K; Jin, J; Hachitanda, M; Murata, Y; Namura, S; Kamichi, S; Kimura, I; et al. (2001). „The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment”. NeuroReport. 12 (13): 2947—50. PMID 11588608. doi:10.1097/00001756-200109170-00038.
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