Propilnorapomorfin
N-n-Propilnorapomorfin (NPA) je derivat aporfina koji deluje kao dopaminski agonist. On je blisko srodan sa apomorfinom.[1][2] Pokazano je da kod glodara između ostalog proizvodi hiperaktivnost, stereotipiju, hipotermiju, antinocepciju, i erekciju.[3][4][5][6]
 | |
| IUPAC ime | |
|---|---|
(6aS)-6-propil-5,6,6a,7-tetrahidro-4H-dibenzo[de,g]hinolin-10,11-diol | |
| Klinički podaci | |
| Način primene | Oralno |
| Pravni status | |
| Pravni status |
|
| Identifikatori | |
| CAS broj | 57559-68-9  |
| ATC kod | none |
| PubChem | CID 5311191 |
| ChemSpider | 4470712 |
| Hemijski podaci | |
| Formula | C19H21NO2 |
| Molarna masa | 295,38 g/mol |
| |
Reference уреди
- ^ Miller RJ, Kelly PH, Neumeyer JL (1976). „Aporphines. 15. Action of aporphine alkaloids on dopaminergic mechanisms in rat brain”. European Journal of Pharmacology. 35 (1): 77—83. PMID 943290. doi:10.1016/0014-2999(76)90302-2.
- ^ Creese I, Padgett L, Fazzini E, Lopez F (1979). „3H-N-n-propylnorapomorphine: a novel agonist ligand for central dopamine receptors”. European Journal of Pharmacology. 56 (4): 411—2. PMID 477735. doi:10.1016/0014-2999(79)90274-7.
- ^ Menon MK, Clark WG, Neumeyer JL (1978). „Comparison of the dopaminergic effects of apomorphine and (-)-N-n-propylnorapomorphine”. European Journal of Pharmacology. 52 (1): 1—9. PMID 569056. doi:10.1016/0014-2999(78)90015-8.
- ^ Riffee WH, Wilcox RE, Smith RV (1979). „Stereotypic and hypothermic effects of apomorphine and N-n-propylnorapomorphine in mice”. European Journal of Pharmacology. 54 (3): 273—7. PMID 570924. doi:10.1016/0014-2999(79)90086-4.
- ^ Neumeyer JL; Reinhard JF; Dafeldecker WP; et al. (1976). „Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines and 10-hydroxy-N-n-propylnoraporphine”. Journal of Medicinal Chemistry. 19 (1): 25—9. PMID 942751. doi:10.1021/jm00223a006.
- ^ Benassi-Benelli A, Ferrari F, Quarantotti BP (1979). „Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats”. Archives Internationales De Pharmacodynamie Et De Thérapie. 242 (2): 241—7. PMID 44457.
