Protoporfirinogen oksidaza (EC 1.3.3.4, protoporfirinogenska IX oksidaza, protoporfirinogenaza, PPO, Protox, HemG, HemY) je enzim sa sistematskim imenom protoporfirinogen-IX:kiseonik oksidoreduktaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

Protoporfirinogen oksidaza
Identifikatori
EC broj1.3.3.4
CAS broj53986-32-6
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
protoporfirinogen IX + 3 O2 protoporfirin IX + 3H2O2

Ovaj enzim je najmanje zastupljen u biosintezi hlorofila i hema. Postoje dva izoenzima kod biljki: jedan u plastidima i drugi u mitohondrijama. On je meta ftalimidnog i difenileterskog tipa herbicida.

Reference уреди

  1. ^ Poulson, R. (1976). „The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX in mammalian mitochondria”. J. Biol. Chem. 251: 3730—3733. PMID 6461. 
  2. ^ Poulson, R. & Polglase, W.J. (1975). „The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX. Protoporphyrinogen oxidase activity in mitochondrial extracts of Saccharomyces cerevisiae”. J. Biol. Chem. 250: 1269—1274. PMID 234450. 
  3. ^ Dailey, H.A. & Dailey, T.A. (1996). „Protoporphyrinogen oxidase of Myxococcus xanthus. Expression, purification, and characterization of the cloned enzyme”. J. Biol. Chem. 271: 8714—8718. PMID 8621504. 
  4. ^ Wang, K.F., Dailey, T.A. and Dailey, H.A. (2001). „Expression and characterization of the terminal heme synthetic enzymes from the hyperthermophile Aquifex aeolicus”. FEMS Microbiol. Lett. 202: 115—119. PMID 11506917. 
  5. ^ Corrigall, A.V., Siziba, K.B., Maneli, M.H., Shephard, E.G., Ziman, M., Dailey, T.A., Dailey, H.A. (1998). „, Kirsch. R.E. and Meissner, P.N. Purification of and kinetic studies on a cloned protoporphyrinogen oxidase from the aerobic bacterium Bacillus subtilis”. Arch. Biochem. Biophys. 358: 251—256. PMID 9784236. 
  6. ^ Ferreira, G.C. & Dailey, H.A. (1988). „Mouse protoporphyrinogen oxidase. Kinetic parameters and demonstration of inhibition by bilirubin”. Biochem. J. 250: 597—603. PMID 2451512. 
  7. ^ Dailey, T.A. & Dailey, H.A. (1996). „Human protoporphyrinogen oxidase: expression, purification, and characterization of the cloned enzyme”. Protein Sci. 5: 98—105. PMID 8771201. 
  8. ^ Che, F.S., Watanabe, N., Iwano, M., Inokuchi, H., Takayama, S., Yoshida, S. and Isogai, A. (2000). „Molecular characterization and subcellular localization of protoporphyrinogen oxidase in spinach chloroplasts”. Plant Physiol. 124: 59—70. PMID 10982422. 
  9. ^ Dailey, T.A. & Dailey, H.A. (1998). „Identification of an FAD superfamily containing protoporphyrinogen oxidases, monoamine oxidases, and phytoene desaturase. Expression and characterization of phytoene desaturase of Myxococcus xanthus”. J. Biol. Chem. 273: 13658—13662. PMID 9593705. 

Literatura уреди

Spoljašnje veze уреди