RAD140

RAD140
IUPAC ime
	2-hloro-4[(1R,2S)-1-[5-(4-cianofenil)-1,3,4-oksadiazol-2-il]-2-hidroksipropil]amino3-metilbenzonitril
Identifikatori
CAS broj	1182367-47-0
PubChem	CID 44200882
ChemSpider	26387625
UNII	4O87Q44KNC
Hemijski podaci
Formula	C20H16ClN5O2
Molarna masa	393,83 g·mol−1
	SMILES ClC1=C(C#N)C=CC(=C1C)N[C@H]([C@H](C)O)C2=NN=C(O2)C3=CC=C(C=C3)C#N; ;
	InChI InChI=1S/C20H16ClN5O2/c1-11-16(8-7-15(10-23)17(11)21)24-18(12(2)27)20-26-25-19(28-20)14-5-3-13(9-22)4-6-14/h3-8,12,18,24,27H,1-2H3/t12-,18+/m0/s1; Key:XMBUPPIEVAFYHO-KPZWWZAWSA-N;

RAD140 je selektivni modulator androgenog receptora (SARM) koji se koristi u istraživaju tretmana za oboljenja kao što su mišićna atrofija i rak dojke. Ovo jedinjenje razvija kompanija Radius Health, Inc. (RDUS).^[1]^[2]^[3]^[4]

Vidi još уреди

Reference уреди

^ Jayaraman, Anusha; Christensen, Amy; Moser, V. Alexandra; Vest, Rebekah S.; Miller, Chris P.; Hattersley, Gary; Pike, Christian J. (2014). „Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats”. Endocrinology. 155 (4): 1398—1406. ISSN 0013-7227. PMC 3959610  . PMID 24428527. doi:10.1210/en.2013-1725.
^ Hamson, D. K.; Wainwright, S. R.; Taylor, J. R.; Jones, B. A.; Watson, N. V.; Galea, L. a. M. (2013). „Androgens Increase Survival of Adult-Born Neurons in the Dentate Gyrus by an Androgen Receptor-Dependent Mechanism in Male Rats”. Endocrinology. 154 (9): 3294—3304. ISSN 0013-7227. PMID 23782943. doi:10.1210/en.2013-1129. ^{[мртва веза]}
^ Miller, Chris P.; Shomali, Maysoun; Lyttle, C. Richard; O’Dea, Louis St. L.; Herendeen, Hillary; Gallacher, Kyla; Paquin, Dottie; Compton, Dennis R.; Sahoo, Bishwabhusan; Kerrigan, Sean A.; Burge, Matthew S.; Nickels, Michael; Green, Jennifer L.; Katzenellenbogen, John A.; Tchesnokov, Alexei; Hattersley, Gary (2011). „Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140”. ACS Medicinal Chemistry Letters. 2 (2): 124—129. PMC 4018048  . PMID 24900290. doi:10.1021/ml1002508.
^ Chris Miller; Maysoun Shomali; C Richard Lyttle; Gary Hattersley (24. 06. 2012). A Selective Androgen Receptor Modulator (RAD140) Induces Inflammation in Rat Right Heart Ventricle: Evidence for an Androgen-Specific, Species-Specific Mechanism. Roles of Androgen & Glucocorticoid Receptors in Physiology & Disease (Translational). Meeting Abstracts. The Endocrine Society. стр. SUN—525—SUN—525. doi:10.1210/endo-meetings.2012.nrsh.9.sun-525.

[1] Jayaraman, Anusha; Christensen, Amy; Moser, V. Alexandra; Vest, Rebekah S.; Miller, Chris P.; Hattersley, Gary; Pike, Christian J. (2014). „Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats”. Endocrinology. 155 (4): 1398—1406. ISSN 0013-7227. PMC 3959610  . PMID 24428527. doi:10.1210/en.2013-1725.

[2] Hamson, D. K.; Wainwright, S. R.; Taylor, J. R.; Jones, B. A.; Watson, N. V.; Galea, L. a. M. (2013). „Androgens Increase Survival of Adult-Born Neurons in the Dentate Gyrus by an Androgen Receptor-Dependent Mechanism in Male Rats”. Endocrinology. 154 (9): 3294—3304. ISSN 0013-7227. PMID 23782943. doi:10.1210/en.2013-1129. ^{[мртва веза]}

[3] Miller, Chris P.; Shomali, Maysoun; Lyttle, C. Richard; O’Dea, Louis St. L.; Herendeen, Hillary; Gallacher, Kyla; Paquin, Dottie; Compton, Dennis R.; Sahoo, Bishwabhusan; Kerrigan, Sean A.; Burge, Matthew S.; Nickels, Michael; Green, Jennifer L.; Katzenellenbogen, John A.; Tchesnokov, Alexei; Hattersley, Gary (2011). „Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140”. ACS Medicinal Chemistry Letters. 2 (2): 124—129. PMC 4018048  . PMID 24900290. doi:10.1021/ml1002508.

[4] Chris Miller; Maysoun Shomali; C Richard Lyttle; Gary Hattersley (24. 06. 2012). A Selective Androgen Receptor Modulator (RAD140) Induces Inflammation in Rat Right Heart Ventricle: Evidence for an Androgen-Specific, Species-Specific Mechanism. Roles of Androgen & Glucocorticoid Receptors in Physiology & Disease (Translational). Meeting Abstracts. The Endocrine Society. стр. SUN—525—SUN—525. doi:10.1210/endo-meetings.2012.nrsh.9.sun-525.

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