Retikulin oksidaza
Retikulin oksidaza (EC 1.21.3.3, BBE, berberinski-most enzim, enzim formiranja berberinskog mosta, tetrahidroprotoberberinska sintaza) je enzim sa sistematskim imenom (S)-retikulin:kiseonik oksidoreduktaza (formira metilinski most).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Retikulin oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.21.3.3 | ||||||||
| CAS broj | 152232-28-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (S)-retikulin + O2 (S)-skoulerin + H2O2
Ovaj enzim sadrži FAD. Enzim iz biljke Eschscholtzia californica kovalentno vezuje kofaktor.
Reference уреди
- ^ Steffens, P., Nagakura, N. and Zenk, M.H. (1984). „The berberine bridge forming enzyme in tetrahydroprotoberberine biosynthesis”. Tetrahedron Lett. 25: 951—952.
- ^ Dittrich, H. & Kutchan, T.M. (1991). „Molecular cloning, expression and induction of the berberine bridge enzyme, an enzyme essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack”. Proc. Natl. Acad. Sci. USA. 88: 9969—9973. PMID 1946465.
- ^ Kutchan, T.M. & Dittrich, H. (1995). „Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in higher plants”. J. Biol. Chem. 270: 24475—24481. PMID 7592663.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Reticuline+oxidase на US National Library of Medicine Medical Subject Headings (MeSH)
