Romboidna proteaza
Romboidna proteaza (EC 3.4.21.105) je enzim.[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Romboidna proteaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.105 | ||||||||
| CAS broj | 713145-02-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Razlaganje tip-1 transmembranskog domena koristeći katalitički par koji se sastoji od serina i histidina koji pripadaju različitim transmembranskim domenima
Ova endopeptidaza je membranski protein koji ima više prolaza kroz membranu.
Reference уреди
- ^ Urban, S. & Wolfe, M.S. (2005). „Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity”. Proc. Natl. Acad. Sci. USA. 102: 1883—1888. PMID 15684070.
- ^ Brossier, F., Jewett, T.J., Sibley, L.D. and Urban, S. (2005). „A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma”. Proc. Natl. Acad. Sci. USA. 102: 4146—4151. PMID 15753289.
- ^ Herlan, M., Bornhovd, C., Hell, K., Neupert, W. and Reichert, A.S. (2004). „Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor”. J. Cell Biol. 165: 167—173. PMID 15096522.
- ^ Pascall, J.C. and Brown, K.D. Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL (2004). „2”. Biochem. Biophys. Res. Commun. 317: 244—252. PMID 15047175.
- ^ Sik, A., Passer, B.J., Koonin, E.V. and Pellegrini, L. (2004). „Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pβ, a nuclear-targeted peptide”. J. Biol. Chem. 279: 15323—15329. PMID 14732705.
- ^ Urban, S. & Freeman, M. (2003). „Substrate specificity of Rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. Mol”. Cell. 11: 1425—1434. PMID 12820957.
- ^ Herlan, M., Vogel, F., Bornhovd, C., Neupert, W. and Reichert, A.S. (2003). „Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA”. J. Biol. Chem. 278: 27781—27788. PMID 12707284.
- ^ McQuibban, G.A., Saurya, S. and Freeman, M. (2003). „Mitochondrial membrane remodelling regulated by a conserved rhomboid protease”. Nature. 423: 537—541. PMID 12774122.
- ^ Koonin, E.V., Makarova, K.S., Rogozin, I.B., Davidovic, L., Letellier, M.C. and Pellegrini, L. (2003). „The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers”. Genome Biol. 4: R19—R19. PMID 12620104.
- ^ Urban, S. & Freeman, M. (2002). „Intramembrane proteolysis controls diverse signalling pathways throughout evolution”. Curr. Opin. Genet. Dev. 12: 512—518. PMID 12200155.
- ^ Urban, S., Schlieper, D. and Freeman, M. (2002). „Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic Rhomboids”. Curr. Biol. 12: 1507—1512. PMID 12225666.
- ^ Urban, S., Lee, J.R. and Freeman, M. (2002). „A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF-like ligands”. EMBO J. 21: 4277—4286. PMID 12169630.
- ^ Urban, S., Lee, J.R. and Freeman, M. (2001). „Drosophila Rhomboid-1 defines a family of putative intramembrane serine proteases”. Cell. 107: 173—182. PMID 11672525.
- ^ Lemberg, M.K., Menendez, J., Misik, A., Garcia, M., Koth, C.M. and Freeman, M. (2005). „Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases”. EMBO J. 24: 464—472. PMID 15616571.
- ^ Wang, Y., Zhang, Y. and Ha, Y. (2006). „Crystal structure of a rhomboid family intramembrane protease”. Nature. 444: 179—180. PMID 17051161.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Rhomboid+protease на US National Library of Medicine Medical Subject Headings (MeSH)
