Sekologanin sintaza
Sekologanin sintaza (EC 1.3.3.9, sekologaninska sintaza) je enzim sa sistematskim imenom loganin:kiseonik oksidoreduktaza (otvaranje prstena).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Sekologanin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.3.9 | ||||||||
| CAS broj | 258339-71-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- loganin + NADPH + H+ + O2 sekologanin + NADP+ + 2H2O
Ovaj enzim je hem-tiolatni protein (P-450). Sekologanin je prekurzor monoterpenoidnih indolnih alkaloida.
Reference уреди
- ^ Yamamoto, H., Katano, N., Ooi, A. and Inoue, K. (2000). „Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P-450”. Phytochemistry. 53: 7—12. PMID 10656401.
- ^ Irmler, S., Schroder, G., St-Pierre, B., Crouch, N.P., Hotze, M., Schmidt, J., Strack, D., Matern, U. and Schroder, J. (2000). „Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P-450 CYP72A1 as secologanin synthase”. Plant J. 24: 797—804. PMID 11135113.
- ^ Yamamoto, H., Katano, N., Ooi, Y. and Inoue, K. (1999). „Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures”. Phytochemistry. 50: 417—422.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Secologanin+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
