Sfingomijelinska fosfodiestaraza
Sfingomijelinska fosfodiestaraza (EC 3.1.4.12, neutralna sfingomijelinaza) je enzim sa sistematskim imenom sfingomielin holinfosfohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Sfingomijelinska fosfodiestaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.1.4.12 | ||||||||
| CAS broj | 9031-54-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- sfingomijelin + H2O keramid + fosfoholin
Ovaj enzim ima neznatnu aktivnost na fosfatidilholinu.
Reference уреди
- ^ Barnholz, Y., Roitman, A. and Gatt, S. (1966). „Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain”. J. Biol. Chem. 241: 3731—3737. PMID 5916388.
- ^ Chatterjee, S. & Ghosh, N. (1989). „Neutral sphingomyelinase from human urine. Purification and preparation of monospecific antibodies”. J. Biol. Chem. 264: 12554—12561. PMID 2545711.
- ^ Heller, M. & Shapiro, B. (1966). „Enzymic hydrolysis of sphingomyelin by rat liver”. Biochem. J. 98: 763—769. PMID 5911524.
- ^ Kanfer, J.N., Young, O.M., Shapiro, D. and Brady, R.O. (1966). „The metabolism of sphingomyelin. I. Purification and properties of a sphingomyelin-cleaving enzyme from rat liver tissue”. J. Biol. Chem. 241: 1081—1084. PMID 5933867.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Sphingomyelin+phosphodiesterase на US National Library of Medicine Medical Subject Headings (MeSH)
