Skvalen monooksigenaza
Skvalen monooksigenaza (EC 1.14.13.132, skvalenska epoksidaza, skvalen-2,3-epoksidna ciklaza, skvalenska 2,3-oksidociklaza, skvalenska hidroksilaza, skvalenska oksidociklaza, skvalen-2,3-epoksidaza) je enzim sa sistematskim imenom skvalen,NADPH:kiseonik oksidoreduktaza (2,3-epoksidacija).[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Skvalen monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.132 | ||||||||
| CAS broj | 9029-62-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- skvalen + NADPH + H+ + O2 (3S)-2,3-epoksi-2,3-dihidroskvalen + NADP+ + H2O
Ovaj enzim je flavoprotein (FAD).
Reference уреди
- ^ Corey, E.J., Russey, W.E. and Ortiz de Montellano, P.R. (1966). „2,3-Oxidosqualene, an intermediate in the biological synthesis of sterols from squalene”. J. Am. Chem. Soc. 88: 4750—4751. PMID 5918046.
- ^ Tchen, T.T. & Bloch, K. (1957). „On the conversion of squalene to lanosterol in vitro”. J. Biol. Chem. 226: 921—930. PMID 13438881.
- ^ van Tamelen, E.E., Willett, J.D., Clayton, R.B. and Lord, K.E. (1966). „Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol”. J. Am. Chem. Soc. 88: 4752—4754. PMID 5918048.
- ^ Yamamoto, S. & Bloch, K. (1970). „Studies on squalene epoxidase of rat liver”. J. Biol. Chem. 245: 1670—1674. PMID 5438357.
- ^ Ono, T. & Bloch, K. (1975). „Solubilization and partial characterization of rat liver squalene epoxidase”. J. Biol. Chem. 250: 1571—1579. PMID 234459.
- ^ Satoh, T., Horie, M., Watanabe, H., Tsuchiya, Y. and Kamei, T. (1993). „Enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae”. Biol. Pharm. Bull. 16: 349—352. PMID 8358382.
- ^ Chugh, A., Ray, A. and Gupta, J.B. (2003). „Squalene epoxidase as hypocholesterolemic drug target revisited”. Prog. Lipid Res. 42: 37—50. PMID 12467639.
- ^ He, F., Zhu, Y., He, M. and Zhang, Y. (2008). „Molecular cloning and characterization of the gene encoding squalene epoxidase in Panax notoginseng”. DNA Seq. 19: 270—273. PMID 17852349.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Squalene+monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
