TRIMU 5

TRIMU 5
Nazivi
	IUPAC naziv L-tyrosyl-N[(3-methylbutyl)amino]acetylD-alaninamide
	Drugi nazivi (2S)-2-amino-3-(4-hydroxyphenyl)-N-[(2R)-1[2-(3-methylbutylamino)acetyl]amino1-oxopropan-2-yl]propanamide
Identifikacija
CAS broj	90815-77-3;
3D model (Jmol)	interaktivna slika;
ChemSpider	21106389 ;
PubChem C ID	5487273;
	SMILES Oc1ccc(C[C@@H](N)C(=O)N[C@H](C)C(=O)NC(=O)CNCCC(C)C)cc1; ; ; ; ; ;
Svojstva
Hemijska formula	C19H30N4O4
Molarna masa	378,466
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

TRIMU 5 je selektivni μ2-agonist/μ1-antagonist mi opioidnog receptora. On stimuliše hipotalamo-hipofizno-adrenalnu osu.^[3]^[4] U eksprerimentima na pacovima TRIMU-5, 50 μg, proizvodi održiv porast kortikosterona u plazmi u toku tročasovnog perioda. Niže doze (10 μg) ne proizvode respons, dok veće doze (100 μg) povišavaju hormonski odgovor, ali su letalne u 50% slučajeva.^[3]

Literatura уреди

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ ^а ^б Eisenberg RM (1994). „TRIMU-5, a mi 2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis”. Pharmacol. Biochem. Behav. 47 (4): 943—6. PMID 8029266. doi:10.1016/0091-3057(94)90300-X.
^ Tive LA, Pick CG, Paul D, Roques BP, Gacel GA, Pasternak GW (1992 Jun 5). „Analgesic potency of TRIMU-5: a mixed mu 2 opioid receptor agonist/mu 1 opioid receptor antagonist”. Eur J Pharmacol. 216 (2): 249—55. PMID 1327812. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

Spoljašnje veze уреди

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[pmid8029266-3] а ^б Eisenberg RM (1994). „TRIMU-5, a mi 2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis”. Pharmacol. Biochem. Behav. 47 (4): 943—6. PMID 8029266. doi:10.1016/0091-3057(94)90300-X.

[pmid1327812-4] Tive LA, Pick CG, Paul D, Roques BP, Gacel GA, Pasternak GW (1992 Jun 5). „Analgesic potency of TRIMU-5: a mixed mu 2 opioid receptor agonist/mu 1 opioid receptor antagonist”. Eur J Pharmacol. 216 (2): 249—55. PMID 1327812. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

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