TRNA-dihidrouridin 16/17 sintaza (NAD(P)+)
tRNA-dihidrouridin 16/17 sintaza [NAD(P)+] (EC 1.3.1.88, Dus1p, tRNK-dihidrouridinska sintaza 1) je enzim sa sistematskim imenom tRNK-5,6-dihidrouracil16/17:NAD(P)+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| TRNA-dihidrouridin 16/17 sintaza [NAD(P)+] | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.88 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) 5,6-dihidrouracil 16 u tRNK + NAD(P)+ uracil 16 u tRNK + NAD(P)H + H+
- (2) 5,6-dihidrouracil 17 u tRNK + NAD(P)+ uracil 17 u tRNK + NAD(P)H + H+
Ovaj enzim je flavoprotein. On specifično modifikuje uracil 16 i uracil 17 u tRNK.
Reference уреди
- ^ Xing, F., Hiley, S.L., Hughes, T.R. and Phizicky, E.M. (2004). „The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs”. J. Biol. Chem. 279: 17850—17860. PMID 14970222.
- ^ Xing, F., Martzen, M.R. and Phizicky, E.M. (2002). „A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA”. RNA. 8: 370—381. PMID 12003496.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- TRNA-dihydrouridine16/17+synthase+(NAD(P)+) на US National Library of Medicine Medical Subject Headings (MeSH)
