Testosteron 17b-dehidrogenaza (NADP+)
Testosteron 17b-dehidrogenaza (NADP+) (EC 1.1.1.64, 17-ketoreduktaza, NADP-zavisna testosteron-17beta-oksidoreduktaza, testosteron 17beta-dehidrogenaza (NADP)) je enzim sa sistematskim imenom 17beta-hidroksisteroid:NADP+ 17-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Testosteron 17b-dehidrogenaza (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.64 | ||||||||
| CAS broj | 9028-63-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- testosteron + NADP+ androstendion + NADPH + H+
Takođe oksiduje 3-hidroksiheksobarbital do 3-oksoheksobarbitala.
Reference уреди
- ^ Endahl, G.L., Kochakia, C.D. and Hamm, D. (1960). „Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine-specific 17β-hydroxy (testosterone) dehydrogenase of guinea pig liver”. J. Biol. Chem. 235: 2792—2796. PMID 13696735.
- ^ Sweat, M.L., Samuels, L.T. and Lumry, R. (1950). „Preparation and characterisation of the enzyme which converts testosterone to androstendione”. J. Biol. Chem. 185: 75—84. PMID 15436478.
- ^ Villee, C.A. & Spencer, J.M. (1960). „Some properties of the pyridine nucleotide-specific 17β-hydroxy steroid dehydrogenase of guinea pig liver”. J. Biol. Chem. 235: 3615—3619. PMID 13781425.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Testosterone+17beta-dehydrogenase+(NADP+) на US National Library of Medicine Medical Subject Headings (MeSH)
