UGT1A5

UGT1A5
Identifikatori
Alijasi	UGT1A5
Spoljašnji ID	OMIM: 606430 HomoloGene: 117984 GeneCards: UGT1A5
Genska ontologija
Molecular function	• glycosyltransferase activity; • transferase activity; • glucuronosyltransferase activity; • hexosyltransferase activity; • UDP-glycosyltransferase activity;
Cellular component	• саставни део мембране; • мембрана; • ендоплазматични ретикулум; • endoplasmic reticulum membrane; • intracellular membrane-bounded organelle;
Biological process	• метаболизам; • xenobiotic glucuronidation; • flavonoid glucuronidation;
	Sources:Amigo / QuickGO
Ortolozi
	54579
	n/a
	ENSG00000288705
	n/a
	P35504
	n/a
	NM_019078
	n/a
	NP_061951
	n/a
	Wikidata
View/Edit Human

UDP-glukuronoziltransferaza 1-5 je enzim koji je kod ljudi kodiran genom UGT1A5.^[2]^[3]^[4]

Reference уреди

^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Entrez Gene: UDP glucuronosyltransferase 1 family”.
^ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (фебруар 1992). „A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini”. J. Biol. Chem. 267 (5): 3257—61. PMID 1339448. doi:10.1016/S0021-9258(19)50724-4  .
^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (август 1997). „The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence”. Pharmacogenetics. 7 (4): 255—69. PMID 9295054. doi:10.1097/00008571-199708000-00001.

Literatura уреди

Yea SS, Lee SS, Kim WY, et al. (2008). „Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population.”. Ther Drug Monit. 30 (1): 23—34. PMID 18223459. S2CID 34396409. doi:10.1097/FTD.0b013e3181633824.
Sanna S, Busonero F, Maschio A, et al. (2009). „Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia”. Hum. Mol. Genet. 18 (14): 2711—8. PMC 2701337  . PMID 19419973. doi:10.1093/hmg/ddp203.
Zhang T, Haws P, Wu Q (2004). „Multiple Variable First Exons: A Mechanism for Cell- and Tissue-Specific Gene Regulation”. Genome Res. 14 (1): 79—89. PMC 314283  . PMID 14672974. doi:10.1101/gr.1225204.
King CD, Rios GR, Green MD, Tephly TR (2000). „UDP-glucuronosyltransferases”. Curr. Drug Metab. 1 (2): 143—61. PMID 11465080. doi:10.2174/1389200003339171.
van Es HH, Bout A, Liu J, et al. (1993). „Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37”. Cytogenet. Cell Genet. 63 (2): 114—6. PMID 8467709. doi:10.1159/000133513.
Gong QH, Cho JW, Huang T, et al. (2001). „Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus”. Pharmacogenetics. 11 (4): 357—68. PMID 11434514. doi:10.1097/00008571-200106000-00011.
Tukey RH, Strassburg CP (2000). „Human UDP-glucuronosyltransferases: metabolism, expression, and disease”. Annu. Rev. Pharmacol. Toxicol. 40: 581—616. PMID 10836148. doi:10.1146/annurev.pharmtox.40.1.581.
Ross CJ, Katzov-Eckert H, Dubé MP, et al. (2009). „Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy”. Nat. Genet. 41 (12): 1345—9. PMID 19898482. S2CID 21293339. doi:10.1038/ng.478.
Johnson AD, Kavousi M, Smith AV, Chen MH, Dehghan A, Aspelund T, Lin JP, van Duijn CM, Harris TB, Cupples LA, Uitterlinden AG, Launer L, Hofman A, Rivadeneira F, Stricker B, Yang Q, O'Donnell CJ, Gudnason V, Witteman JC (јул 2009). „Genome-wide association meta-analysis for total serum bilirubin levels”. Hum. Mol. Genet. 18 (14): 2700—10. PMC 2701336  . PMID 19414484. doi:10.1093/hmg/ddp202.

[1] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-2] „Entrez Gene: UDP glucuronosyltransferase 1 family”.

[pmid1339448-3] Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (фебруар 1992). „A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini”. J. Biol. Chem. 267 (5): 3257—61. PMID 1339448. doi:10.1016/S0021-9258(19)50724-4  .

[pmid9295054-4] Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (август 1997). „The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence”. Pharmacogenetics. 7 (4): 255—69. PMID 9295054. doi:10.1097/00008571-199708000-00001.

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[4]

[1]