XPB (Xeroderma Pigmentosum B) je ATP zavisna ljudska DNK helikaza koja je deo kompleksa TFIIH transkripcionog faktora. 3D struktura XPB homologa je kristalografski.[1]

Identifikatori
Simboli ERCC3; BTF2; GTF2H; RAD25; TFIIH; XPB
Vanjski ID OMIM133510 MGI95414 HomoloGene96 GeneCards: ERCC3 Gene
EC broj 3.6.4.12
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2071 13872
Ensembl ENSG00000163161 ENSMUSG00000024382
UniProt P19447 P49135
RefSeq (mRNA) NM_000122.1 NM_133658.1
RefSeq (protein) NP_000113.1 NP_598419.1
Lokacija (UCSC) Chr 2:
128.01 - 128.05 Mb
Chr 18:
32.4 - 32.43 Mb
PubMed pretraga [1] [2]

Funkcija

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XPB učestvuje u normalnoj bazalnoj transkripciji, transkripciono spregnutoj popravci (TCR), i popravci isecanjem nukleotida (NER). Pokazano jed a prečišćeni XPB razvija DNK u 3’-5’ pravcu.

Interakcije

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XPB formira interakcije sa XPC,[2] BCR genom,[3] ERCC2,[4][5][6][7] P53,[8] GTF2H2,[4][5] GTF2H1,[4][5][9] GTF2H5,[4] ciklin zavisnom kinazom,[4][9][10] PSMC5[11] i GTF2H4.[4][5]

Literatura

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Reference

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  1. ^ Fan L, Arvai A, Cooper P, Iwai S, Hanaoka F, Tainer J (2006). „Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair”. Mol Cell. 22 (1): 27—37. PMID 16600867. doi:10.1016/j.molcel.2006.02.017. 
  2. ^ Yokoi, M; et al. (2000). „The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA”. J. Biol. Chem. UNITED STATES. 275 (13): 9870—5. ISSN 0021-9258. PMID 10734143. doi:10.1074/jbc.275.13.9870. 
  3. ^ Takeda, N; et al. (1999). „The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 96 (1): 203—7. ISSN 0027-8424. PMC 15117 . PMID 9874796. doi:10.1073/pnas.96.1.203. 
  4. ^ а б в г д ђ Giglia-Mari, Giuseppina; et al. (2004). „A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A”. Nat. Genet. United States. 36 (7). ISSN 1061-4036. PMID 15220921. doi:10.1038/ng1387. 
  5. ^ а б в г Marinoni, J C; et al. (1997). „Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH”. EMBO J. ENGLAND. 16 (5): 714—9. ISSN 0261-4189. PMC 1169708 . PMID 9118947. doi:10.1093/emboj/16.5.1093. 
  6. ^ Drapkin, R; et al. (1994). „Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II”. Nature. ENGLAND. 368 (6473): 769—72. ISSN 0028-0836. PMID 8152490. doi:10.1038/368769a0. 
  7. ^ Iyer, N; et al. (1996). „Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein”. Biochemistry. UNITED STATES. 35 (7): 2157—67. ISSN 0006-2960. PMID 8652557. doi:10.1021/bi9524124. 
  8. ^ Wang, X W; et al. (1995). „p53 modulation of TFIIH-associated nucleotide excision repair activity”. Nat. Genet. UNITED STATES. 10 (2): 188—95. ISSN 1061-4036. PMID 7663514. doi:10.1038/ng0695-188. 
  9. ^ а б Rossignol, M; et al. (1997). „Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH”. EMBO J. ENGLAND. 16 (7): 1628—37. ISSN 0261-4189. PMC 1169767 . PMID 9130708. doi:10.1093/emboj/16.7.1628. 
  10. ^ Yee, A; et al. (1995). „Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor”. Cancer Res. UNITED STATES. 55 (24): 6058—62. ISSN 0008-5472. PMID 8521393. 
  11. ^ Weeda, G; et al. (1997). „The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor”. Nucleic Acids Res. ENGLAND. 25 (12): 2274—83. ISSN 0305-1048. PMC 146752 . PMID 9173976. doi:10.1093/nar/25.12.2274. 

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