Cikloastragenol

Cikloastragenol
Nazivi
	Drugi nazivi Ciklogalegigenin, Astramembrangenin, TA-65
Identifikacija
CAS broj	84605-18-5 ;
PubChem C ID	44144539;
Svojstva
Hemijska formula	C30H50O5
Molarna masa	490,72 g/mol
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Cikloastragenol je sapogenin koji je prisutan u biljci Astragalus membranaceus.^[3] On je u prodaji pod imenima TA-65 ili TA-65MD u SAD-u. Proizvodi ga kompanija Telomerase Activation Sciences, Inc.. TA-65 se pojavio na tržištu 2005.

Cikloastragenol umereno povećava aktivnost telomeraze i proliferativni kapacitet CD4 i CD8 T ćelija.^[4] Postoje indikacije da je on posebno efektivan kod citomegalovirus-pozitivnih osoba.^[5]

Reference уреди

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Fauce, SR; Jamieson, BD; Chin, AC; Mitsuyasu, RT; Parish, ST; Ng, HL; Kitchen, CM; Yang, OO; et al. (2008). „Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes”. Journal of immunology. 181 (10): 7400—6. PMC 2682219  . PMID 18981163.
^ Valenzuela, Hector F; Fuller, Thomas; Edwards, Jim; Finger, Danielle; Molgora, Brenda (2009). „Cycloastragenol extends T cell proliferation by increasing telomerase activity”. The Journal of Immunology. 182 (Meeting Abstract Supplement).
^ Harley, Calvin B; Liu, Weimin; Blasco, Maria; Vera, Elsa; Andrews, William H; Briggs, Laura A; Raffaele, Joseph M (1. 2. 2011). „A Natural Product Telomerase Activator As Part of a Health Maintenance Program”. Rejuvenation Research. 14 (1): 45—56. doi:10.1089/rej.2010.1085.

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u vezi sa temama iz oblasti medicine (zdravlja).

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[3] Fauce, SR; Jamieson, BD; Chin, AC; Mitsuyasu, RT; Parish, ST; Ng, HL; Kitchen, CM; Yang, OO; et al. (2008). „Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes”. Journal of immunology. 181 (10): 7400—6. PMC 2682219  . PMID 18981163.

[4] Valenzuela, Hector F; Fuller, Thomas; Edwards, Jim; Finger, Danielle; Molgora, Brenda (2009). „Cycloastragenol extends T cell proliferation by increasing telomerase activity”. The Journal of Immunology. 182 (Meeting Abstract Supplement).

[5] Harley, Calvin B; Liu, Weimin; Blasco, Maria; Vera, Elsa; Andrews, William H; Briggs, Laura A; Raffaele, Joseph M (1. 2. 2011). „A Natural Product Telomerase Activator As Part of a Health Maintenance Program”. Rejuvenation Research. 14 (1): 45—56. doi:10.1089/rej.2010.1085.

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