|
Postoje dve glavne grupe adrenergičkih receptora, α i β:
* α receptori obuhvataju podtipove [[Alfa-1 adrenergički receptor|α<sub>1</sub>]] ([[G protein|-{G<sub>q</sub>}-]] spregnuti receptor) i [[Alfa-2 adrenergički receptor|α<sub>2</sub>]] (-{G<sub>i</sub>}- spregnuti receptor). [[Fenilefrin]] je selektivni [[Agonist (farmakologija)|agonist]] α receptora.
* β receptori obuhvataju podtipove [[Beta-1 adrenergički receptor|β<sub>1</sub>]], [[Beta-2 adrenergički receptor|β<sub>2</sub>]] i [[Beta-3 adrenergički receptor|β<sub>3</sub>]]. Sva tri receptora vezuju -{G<sub>s</sub>}- proteine (mada se [[Beta-2 adrenergički receptor|β<sub>2</sub>]] takođe spreže sa -{Gi}-),<ref name="pmid11053129">{{cite journal | author vauthors= Chen-Izu Y, Xiao RP, Izu LT, Cheng H, Kuschel M, Spurgeon H, Lakatta EG | title = G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels | journal = Biophys. J. | volume = 79 | issue = 5 | pages = 2547–56 | year = 2000 | month = November | pmid = 11053129 | pmc = 1301137 | doi = 10.1016/S0006-3495(00)76495-2 | url = }}</ref> koji aktivira signalni put [[adenilat ciklaza|adenilat ciklaze]]. Vezivanje agonista uzrokuje povišenje intracelularne koncentracije sekundarnog glasnika [[Ciklični adenozin monofosfat|cAMP]]. Nizvodni cAMP efektor je [[cAMP-zavisna proteinska kinaza]] (-{PKA}-), koja posreduje neke od intracelularnih događaja nakon hormonskog vezivanja. [[Izoprenalin]] je selektivni agonist.
=== Uloge u cirkulaciji ===
== Dodatna literatura ==
{{refbegin|2}}
* {{Cite book |ref= harv|first = | last vauthors=Rang HP, Dale MM, Ritter JM, Moore PK| authorlink = | coauthors = | year = 2003| month = | title = Pharmacology | chapter = Chapter 11: Noradrenergic transmission | editor = | others = | edition = 5<sup>th</sup>5th | publisher = Elsevier Churchill Livingstone| location = |id=ISBN 0-443-07145-4| url = }}
* {{Cite book |ref= harv|first = | last vauthors=Rang HP, Dale MM, Ritter JM, Flower RJ| authorlink = | coauthors = | year = 2007| month = | title = Rang and Dale's Pharmacology | chapter = Chapter 11: Noradrenergic transmission | editor = | others = | edition = 6<sup>th</sup>6th | pages = 169–170 | publisher = Elsevier Churchill Livingstone| location = |id=ISBN 0-443-06911-5| url = }}
{{refend}}
* [http://pharmacologycorner.com/alpha-receptors-1-2/ Alfa receptori]
* [http://macromoleculeinsights.com/adrenergic.php Adrenergički receptori]
* {{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1274 | title = Adrenoceptors | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
* [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=bnchm.section.890 α- i β-adrenergički receptori]
* [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109691 Sažeti pregled funkcija beta-3 receptora]
| 