Metabolom — разлика између измена

'''Metabolom'''<ref name="FirstUse"> Prva upotreba termina ''metabolom'' u literaturi – {{cite journal |authorvauthors=Oliver SG, Winson MK, Kell DB, Baganz F |title=Systematic functional analysis of the yeast genome |journal=Trends Biotechnol. |volume=16 |issue=9 |pages=373–8 |year=1998 |month=September |pmid=9744112 |doi= 10.1016/S0167-7799(98)01214-1|url=http://linkinghub.elsevier.com/retrieve/pii/S0167-7799(98)01214-1}}</ref> se odnosi na kompletni set malih-molekulskih metabolita (kao što su intermedijeri, hormoni i drugi signalni molekuli, kao i sekundarni metaboliti) koji se može naći u biološkom uzorku, kao što je jednostavni organizam. Reč je skovana po analogiji sa [[transkriptomika|transkriptomikom]] i [[proteomika|proteomikom]], kao što su [[transkriptom]] i [[proteom]], metabolom je dinamičan, i menja se od sekunde do sekunde. Mada se metabolom može dovoljno jasno definisati, još uvek nije moguće analizirati [[metabolomika|celokupan opseg metabolita]] jednim analitičkim metodom. Januara [[2007]] naučnici sa [[Alberta]] univerziteta i [[Kalgari]] univerziteta su završili nacrt ljudskog metaboloma. Oni su kategorizovali i karakterizovali 2,500 [[metaboliti|metabolita]], 1,200 [[lek]]ova i 3,500 komponenti hrane koji se mogu naći u ljudskom telu.<ref>Prva knjiga o metabolomici – {{Cite book | author=Harrigan, G. G. & Goodacre, R. (eds) | title=RMetabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis | publisher=Kluwer Academic Publishers (Boston) | year=2003 |id=xxx-xxx}}</ref><ref>{{cite journal |authorvauthors=Fiehn O, Kloska S, Altmann T |title=Integrated studies on plant biology using multiparallel techniques |journal=Curr. Opin. Biotechnol. |volume=12 |issue=1 |pages=82–6 |year=2001 |month=February |pmid=11167078 |doi= 10.1016/S0958-1669(00)00165-8|url=http://linkinghub.elsevier.com/retrieve/pii/S0958-1669(00)00165-8}}</ref><ref>{{cite journal |author=Fiehn O |title=Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks |journal=Comp. Funct. Genomics |volume=2 |issue=3 |pages=155–68 |year=2001 |pmid=18628911 |pmc=2447208 |doi=10.1002/cfg.82 |url=}}</ref>

* {{cite journal |authorvauthors=Goodacre R, Vaidyanathan S, Dunn WB, Harrigan GG, Kell DB |title=Metabolomics by numbers: acquiring and understanding global metabolite data |journal=Trends Biotechnol. |volume=22 |issue=5 |pages=245–52 |year=2004 |month=May |pmid=15109811 |doi=10.1016/j.tibtech.2004.03.007 |url=}}

* {{cite journal |authorvauthors=Wishart DS, Tzur D, Knox C, Eisner R, Guo AC, Young N, Cheng D, Jewell K, Arndt D, Sawhney S, Fung C, Nikolai L, Lewis M, Coutouly M-A, Forsythe I, Tang P, Shrivastava S, Jeroncic K, Stothard P, Amegbey G, Block D, Hau DD, Wagner J, Miniaci J, Clements M, Gebremedhin M, Guo N, Zhang Y, Duggan GE, MacInnis GD, Weljie AM, Dowlatabadi R, Bamforth F, Clive D, Greiner R, Li L, Marrie T, Sykes BD, Vogel HJ, Querengesser L |title= '''HMDB: The Human Metabolome Database''' |journal=Nucleic Acids Research |volume=35 (Database issue) |pages=D521–6 |year= 2007 |month=January |doi=10.1093/nar/gkl923 |url= |pmid= 17202168}}

* {{cite journal |authorvauthors=Wishart DS, Knox C, Guo AC, Eisner R, Young N, Gautam B, Hau DD, Psychogios N, Dong E, Bouatra S, Mandal R, Sinelnikov I, Xia J, Jia L, Cruz JA, Lim E, Sobsey CA, Shrivastava S, Huang P, Liu P, Fang L, Peng J, Fradette R, Cheng D, Tzur D, Clements M, Lewis A, De Souza A, Zuniga A, Dawe M, Xiong Y, Clive D, Greiner R, Nazyrova A, Shaykhutdinov R, Li L, Vogel HJ, Forsythe I |title='''HMDB: a knowledgebase for the human metabolome''' |journal=Nucleic Acids Research |volume=37 (Database issue) |pages=D603–10 |year= 2009 |month=January |doi=10.1093/nar/gkn810 |url= |unused data=|pmid=18953024}}

* {{cite journal |authorvauthors=Nicholson JK, Holmes E, Lindon JC, Wilson ID |title=The challenges of modeling mammalian biocomplexity |journal=Nat. Biotechnol. |volume=22 |issue=10 |pages=1268–74 |year=2004 |month=October |pmid=15470467 |doi=10.1038/nbt1015 |url=}}. Stresses the role of intestinal microorganisms in contributing to the human metabolome.

* {{cite journal |authorvauthors=van der Greef J, Stroobant P, van der Heijden R |title=The role of analytical sciences in medical systems biology |journal=Curr Opin Chem Biol |volume=8 |issue=5 |pages=559–65 |year=2004 |month=October |pmid=15450501 |doi=10.1016/j.cbpa.2004.08.013 |url=}}

* {{cite journal |authorvauthors=Ellis DI, Goodacre R |title=Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy |journal=Analyst |volume=131 |issue=8 |pages=875–85 |year=2006 |month=August |pmid=17028718 |doi=10.1039/b602376m |url=}}