Metabolomika — разлика између измена

'''Metabolomika''' je naučna studija hemijskih procesa u kojima učestvuju [[metabolit]]i. Metabolomika je sistematsko izučavanje jedinstvenih hemijskih otisaka koji su specifčni za ćelijske procese. Ona je studija motaboličkih profila malih molekula.<ref>{{cite journal |first1=Bennett |last=Daviss|month=April |year=2005 |title=Growing pains for metabolomics |journal=The Scientist |volume=19 |issue=8 |pages=25–28 |url=http://www.the-scientist.com/article/display/15427/}}</ref> [[Metabolom]] je kolekcija svih metabolita u biološkoj ćeliji, tkivu, organu ili organizmu, koji su krajnji produkti ćelijskih procesa.<ref>{{cite journal |authorvauthors=Jordan KW, Nordenstam J, Lauwers GY, Rothenberger DA, Alavi K, Garwood M, Cheng LL |title=Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy |journal=Diseases of the Colon & Rectum |volume=52 |issue=3 |pages=520–5 |year=2009 |month=March |pmid=19333056 |doi=10.1007/DCR.0b013e31819c9a2c |url= |pmc=2720561}}</ref> Dok celokupni podaci [[iRNK]] [[genska ekspresija|genske ekspresije]] i [[proteomika|proteomskih]] analiza ne sadrže potpunu informaciju o ćelijskim procesima, metabolički profil može da pruži trenutnu sliku ćelijske fiziologije. Jedan od izazova [[sistemska biologija|sistemske biologije]] i [[funkcionalna genomika|funkcionalne genomike]] je integracija [[proteomika|proteomske]], [[transkriptomika|transkriptomske]], i metabolomske informacije da bi se formirala kompletnija slika živih organizama.

* {{Cite book |ref= harv|authorvauthors=Tomita M, Nishioka T |year=2005 |title=Metabolomics: The Frontier of Systems Biology |publisher=Springer |id=ISBN 4-431-25121-9}}

* {{cite journal | author vauthors= Fan TW, Lorkiewicz PK, Sellers K, Moseley HN, Higashi RM, Lane AN | title = Stable isotope-resolved metabolomics and applications for drug development | journal = Pharmacol. Ther. | volume = 133 | issue = 3 |pages=366–91 |year=2012 | month = March | pmid = 22212615 | pmc = 3471671 | doi = 10.1016/j.pharmthera.2011.12.007 }}

* {{cite journal |authorvauthors=Ellis DI, Goodacre R |year=2006 | title = Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy |journal = Analyst | volume = 131 | issue = 8|pages=875–885 | doi = 10.1039/b602376m | pmid = 17028718 |url=http://dbkgroup.org/dave_files/AnalystMetabolicFingerprinting2006.pdf|bibcode = 2006Ana...131..875E }}

* {{Cite journal |authorvauthors=Ellis DI, Dunn WB, Griffin JL, Allwood JW, Goodacre R |year=2007 |title=Metabolic fingerprinting as a diagnostic tool |journal=Pharmacogenomics |volume=8 |issue=9 |pages=1243–1266 |url=http://dbkgroup.org/dave_files/Pharmacogenomics.pdf |doi=10.2217/14622416.8.9.1243 |pmid=17924839}}