Obestatin — разлика између измена

|caption=[[Nuklearna magnetna rezonancija|NMR structura]] obestatina u [[natrijum lauril sulfat|-{SDS}-]] / [[dodecilfosfoholin|-{DPC}-]] [[micela|micelnom]] rastvoru.<ref name="pmid17904104">{{PDB|2JSH}}; {{cite journal |vauthors=Scrima M, Campiglia P, Esposito C, Gomez-Monterrey I, Novellino E, D'Ursi AM | title = Obestatin conformational features: a strategy to unveil obestatin's biological role? | journal = Biochem. Biophys. Res. Commun. | volume = 363 | issue = 3 | pages = 500–5 | year = 2007 | month = November | pmid = 17904104 | doi = 10.1016/j.bbrc.2007.08.200 | url = | issn = }}</ref>

'''Obestatin''' je putativni [[hormon]] koji se potencijalno proizvodi u ćelijama sluzokože [[želudac|želuca]] i [[tanko crevo|tankih creva]] kod nekoliko [[sisar]]a među kojima je [[čovek]].<ref name="pmid17321609">{{cite journal |vauthors=Gourcerol G, St-Pierre DH, Taché Y | title = Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)? | journal = Regul. Pept. | volume = 141 | issue = 1-3 | pages = 1–7 | year = 2007 | month = June | pmid = 17321609 | doi = 10.1016/j.regpep.2006.12.023 | url = | issn = }}</ref> Obestatin je originalno bio identifikovan kao [[anoreksija|anoreksioni]] [[peptid]], mada njegov uticaj na unos hrane ostaje kontroverzan.<ref name="pmid20456603">{{cite journal |vauthors=Hassouna R, Zizzari P, Tolle V | title = The ghrelin/obestatin balance in the physiological and pathological control of growth hormone secretion, body composition and food intake | journal = J. Neuroendocrinol. | volume = 22 | issue = 7 | pages = 793–804 | year = 2010 | month = July | pmid = 20456603 | doi = 10.1111/j.1365-2826.2010.02019.x | url = | issn = }}</ref>

Istraživanja u Medicinskoj školi [[Stanford (univerzitet)|univerziteta u Stanfordu]] su identifikovala obestatin kao hormon [[2005]]. godine. Do otkrića je došlo korišćenjem [[bioinformatika|bioinformatičkog]] pristupa računarske pretrage sekvenciranih [[genom]]a nekoliko organizama.<ref name="pmid16284174">{{cite journal |vauthors=Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ | title = Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake | journal = Science | volume = 310 | issue = 5750 | pages = 996–9 | year = 2005 | month = November | pmid = 16284174 | doi = 10.1126/science.1117255 | laysummary = http://nytimes.com/2005/11/11/health/11hunger.html | laysource = New York Times }}</ref>