Supstanca P — разлика између измена

U [[neuronauka|neuronauci]] '''supstanca P''' (SP) je [[neuropeptid]]: undekapeptid koji funkcioniše kao [[neurotransmiter]] i [[neuromodulator]].<ref name="pmid11378438">{{cite journal |vauthors=Harrison S, Geppetti P | title = Substance p | journal = The International Journal of Biochemistry & Cell Biology | volume = 33 | issue = 6 | pages = 555–76 | year = 2001 | month = June | pmid = 11378438 | doi = 10.1016/S1357-2725(01)00031-0 | url = }}</ref><ref name="pmid14754378">{{cite journal |vauthors=Datar P, Srivastava S, Coutinho E, Govil G | title = Substance P: structure, function, and therapeutics | journal = Current topics in medicinal chemistry | volume = 4 | issue = 1 | pages = 75–103 | year = 2004 | pmid = 14754378 | doi = 10.2174/1568026043451636| url = http://www.bentham-direct.org/pages/content.php?CTMC/2004/00000004/00000001/0009R.SGM }}</ref> Ovaj molekul pripada familiji [[tahikinin]]skih neuropeptida. Supstanca P i njen blisko srodni neuropeptid [[neurokinin A]] (NKA) nastaju iz poliproteinskog prekurzora nakon diferencijalnog splajsovanja gena preprotahikinina A. Aminokiselinska sekvenca supstance P je<ref name="pmid">{{cite journal |vauthors=Chang MM, Leeman SE, Niall HD | title = Amino-acid sequence of substance P | journal = Nature: New Biology | volume = 232 | issue = 29 | pages = 86–7 | year = 1971 | month = July | pmid = | doi = | url = | issn = | accessdate = 31. 03. 2011.}}</ref><ref name="pmid4613983">{{cite journal |vauthors=Leeman SE, Mroz EA | title = Substance P | journal = Life Sciences | volume = 15 | issue = 12 | pages = 2033–44 | year = 1974 | month = December | pmid = 4613983 | doi = | url = | issn = | accessdate = 31. 03. 2011.}}</ref>:

Supstancu P su originalno otkrili [[1931]] Ulf von Euler i Džon H. Gadum kao extrakt tkiva koji izaziva intestinalne kontrakcije -{''in vitro''}-.<ref name="pmid16994201">{{cite journal |vauthors=V Euler US, Gaddum JH | title = An unidentified depressor substance in certain tissue extracts | journal = The Journal of Physiology | volume = 72 | issue = 1 | pages = 74–87 | year = 1931 | month = June | pmid = 16994201 | pmc = 1403098 | doi = | url = http://www.jphysiol.org/cgi/pmidlookup?view=long&pmid=16994201 | issn = }}</ref> Njena distribucija u tkivu i biološka dejstva su detaljno ispitivana tokom decenija koje su sledele.<ref name="pmid11378438"/> NKA (prethodno poznata kao supstanca K ili neuromedin L) je izolovana iz [[svinja|svinjske]] [[kičmena moždina|kičmene moždine]] [[1983]], i ustanovljeno je da takođe stimuliše intestinalne kontrakcije.<ref name="pmid6194276">{{cite journal |vauthors=Panula P, Hadjiconstantinou M, Yang HY, Costa E | title = Immunohistochemical localization of bombesin/gastrin-releasing peptide and substance P in primary sensory neurons | journal = The Journal of Neuroscience : the official journal of the Society for Neuroscience | volume = 3 | issue = 10 | pages = 2021–9 | year = 1983 | month = October | pmid = 6194276 | doi = | url = http://www.jneurosci.org/cgi/content/abstract/3/10/2021 | issn = }}</ref>

[[Endogen]]i [[receptor (biohemija)|receptor]] supstance P je [[tahikininski receptor 1|neurokininski 1]] receptor (NK1-receptor, NK1R).<ref name="pmid1657150">{{cite journal |vauthors=Gerard NP, Garraway LA, Eddy RL Jr, Shows TB, Iijima H, Paquet JL, Gerard C | title = Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones | journal = Biochemistry | volume = 30 | issue = 44 | pages = 10640–6 | year = 1991 | month = November | pmid = 1657150 | doi = 10.1021/bi00108a006| url = }}</ref> On pripada familiji [[tahikininski receptor|tahikininskih receptora]] [[G protein spregnuti receptori|G protein-spregnutih receptora]].<ref name="pmid7557266">{{cite journal | author = Maggi CA |title = The mammalian tachykinin receptors | journal = Gen. Pharmacol. | volume = 26 | issue = 5 | pages = 911–44 | year = 1995 | pmid = 7557266 | doi = 10.1016/0306-3623(94)00292-U }}</ref>