Sistemska biologija — разлика између измена
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[[Датотека:Genomics GTL Pictorial Program.jpg|мини|320px|Ilustracija sistemskog pristupa biologiji]]
'''Sistemska biologija''' je holistički pristup biomedicinskim i biološkim naučnim istraživanjima (za razliku od tradicionalnog [[Редукционизам|reduktionizma]]). Sistemska biologija je interdisciplinarno polje bazirano na [[biologija|biologiji]] sa fokusom na kompleksnim interakcijama unutar [[Organski sistem|bioloških sistema]]. Ovaj koncept je u širokoj upotrebi u [[Biologija|bionaukama]] u više različitih konteksta, pogotovo nakon 2000. godine. Jedan od primarnih ciljeva ove naučne oblasti je razvoj modela i otkrivanje svojstava koja se manifestuju kad [[ćelija (biologija)|ćelija]], [[tkivo (biologija)|tkivo]] i organizam funkcionišu kao celina ([[sistem]]), i čije je teoretsko opisivanje jedino moguće koristeći tehnike u domenu sistemske biologije. Realizacija tih ciljeva obično obuhvata izučavanje [[metabolička mreža|metaboličkih]] ili [[Ћелијска комуникација|signalnih mreža]].<ref name="pmid21570668">{{cite journal | author = Bu Z, Callaway DJ | title = Proteins MOVE! Protein dynamics and long-range allostery in cell signaling | journal = Advances in Protein Chemistry and Structural Biology | volume = 83 | issue = |pages=163-221 | year = 2011 | pmid = 21570668 | doi = 10.1016/B978-0-12-381262-9.00005-7 | url = |series=Advances in Protein Chemistry and Structural Biology | isbn = 978-0-123-81262-9| pages = }}</ref>
== Pregled ==
Ред 17:
== Reference ==
{{reflist|2| refs =
<ref name="snoep05">{{cite journal | last1 = Snoep | first1 = Jacky L | last2 = Westerhoff | first2 = Hans V | editor1-last = Alberghina | editor1-first = Lilia | editor2-last = Westerhoff | editor2-first = Hans V | year = 2005 | title = Systems Biology: Definitions and Perspectives | volume = 13 | pages=13-30 | location = Berlin | publisher = Springer-Verlag | doi = 10.1007/b106456 | chapter = From isolation to integration, a systems biology approach for building the Silicon Cell | series = Topics in Current Genetics | isbn = 978-3-540-22968-1| pages = }}</ref>
<ref name="21stcentury">{{cite web | url = http://www.systemsbiology.org/Intro_to_Systems_Biology/Systems_Biology_--_the_21st_Century_Science | title = Systems Biology: the 21st Century Science | publisher = Institute for Systems Biology | accessdate = 15. 6. 2011. |archive-url = https://web.archive.org/web/20110610195249/http://www.systemsbiology.org/Intro_to_Systems_Biology/Systems_Biology_--_the_21st_Century_Science |archive-date = 10. 06. 2011 |dead-url = yes |df = }}</ref>
Zeng BJ. , On the concept of systems biological engineering, Nov. 1994, Communication on Transgenic Animals, CAS, China.
<ref name="sauer07">{{cite journal | last1 = Sauer | first1 = Uwe | last2 = Heinemann | first2 = Matthias | last3 = Zamboni | first3 = Nicola | date = 27. 4. 2007. | journal = Science | volume = 316 | issue = 5824 | pages=550-551 | pmid = 17463274 | doi = 10.1126/science.1142502 | title = GENETICS: Getting Closer to the Whole Picture }}</ref>
Ред 27:
<ref name="noble06">{{harvnb|Noble|2006|pp=176}}</ref>
<ref name="kholodenko05">{{cite journal | last1 = Kholodenko | first1 = Boris N | last2 = Sauro | first2 = Herbert M | editor1-last = Alberghina | editor1-first = Lilia | editor2-last = Westerhoff | editor2-first = Hans V | year = 2005 | title = Systems Biology: Definitions and Perspectives | volume = 13 | pages=357-451 | location = Berlin | publisher = Springer-Verlag | doi = 10.1007/b136809 | chapter = Mechanistic and modular approaches to modeling and inference of cellular regulatory networks | series = Topics in Current Genetics | isbn = 978-3-540-22968-1| pages = }}</ref>
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Ред 33:
== Literatura ==
{{refbegin|2}}
* {{Cite book | ref = harv| last = Noble| first = Denis | title = The music of life: Biology beyond the genome | year = 2006 | publisher = Oxford University Press | location = Oxford | isbn = 978-0-19-929573-9 | pages = 176 }}
* {{Cite journal | editor = Asfar S. Azmi | title = Systems Biology in Cancer Research and Drug Discovery | isbn = 978-94-007-4819-4| pages = 423 | year = 2012 }}
* {{Cite book | ref = harv| last = Kitano| first = Hiroaki | title = Foundations of Systems Biology | year = 2001 | publisher = MIT Press | isbn = 978-0-262-11266-6 | pages = 320 }}
* {{cite journal | last1 = Werner | first1 = Eric | date = 29. 3. 2007. | title = All systems go | journal = Nature | volume = 446 | pages=493-494 | doi = 10.1038/446493a | issue = 7135 | bibcode = 2007Natur.446..493W }} provides a comparative review of three books:
* {{Cite book | ref = harv| last = Alon| first = Uri | title = An Introduction to Systems Biology: Design Principles of Biological Circuits | year = 2006 | publisher = Chapman & Hall | isbn = 978-1-58488-642-6 | pages = 301 }}
* {{Cite book | ref = harv| last = Kaneko| first = Kunihiko | title = Life: An Introduction to Complex Systems Biology | year = 2006 | publisher = Springer-Verlag | isbn = 978-3-540-32666-3 | pages = 371 }}
* {{Cite book | ref = harv| last = Palsson| first = Bernhard O | title = Systems Biology: Properties of Reconstructed Networks | year = 2006 | publisher = Cambridge University Press | isbn = 978-0-521-85903-5 | pages = 334 }}
* {{Cite book | ref = harv| editor = Werner Dubitzky, Olaf Wolkenhauer, Hiroki Yokota, Kwan-Hyun Cho | title = Encyclopedia of Systems Biology | year = 2013 | publisher = Springer-Verlag | isbn = 978-1-4419-9864-4| pages = 2100 }}
{{refend}}
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