Ligaza — разлика између измена

 

 

 

 

 

The common names of ligases often include the word "ligase", such as [[DNA ligase]], an enzyme commonly used in molecular biology [[laboratory|laboratories]] to join together [[DNA]] fragments. Other common names for ligases include the word "synthetase", because they are used to [[biosynthesis|synthesize]] new molecules.

 

Biochemical nomenclature has sometimes distinguished synthetases from [[synthase]]s and sometimes treated the words as [[synonym]]s. Under one definition, synthases ''do not'' use energy from [[nucleoside triphosphate]]s (such as ATP, GTP, CTP, TTP, and UTP), whereas synthetases ''do'' use nucleoside triphosphates. It is also said that a synthase is a [[lyase]] (a lyase is an enzyme that catalyzes the breaking of various chemical bonds by means other than hydrolysis and oxidation, often forming a new double bond or a new ring structure) and does not require any energy, whereas a synthetase is a ligase (a ligase is an enzyme that binds two chemicals or compounds) and thus requires energy. However, the [[Joint Commission on Biochemical Nomenclature]] (JCBN) dictates that "synthase" can be used with any enzyme that catalyses synthesis (whether or not it uses nucleoside triphosphates), whereas "synthetase" is to be used synonymously.<ref>{{cite web|url=http://www.chem.qmul.ac.uk/iubmb/newsletter/misc/synthase.html |title=Synthases and ligases |work=chem.qmul.ac.uk |date= |accessdate=July 28, 2013}}</ref>

 

 

 

 

 

 

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